Abdominopelvic Imaging: GastrointestinalCan Posttransarterial Chemoembolization Volumetric Oil Deposition on Computed Tomography Predict Treatment Response on Magnetic Resonance Imaging in Leiomyosarcoma Metastases to the Liver?Hazhirkarzar, Bita MD∗; Shaghaghi, Mohammadreza MD, MPH∗; Baghdadi, Azarakhsh MD, MAS∗; Ghadimi, Maryam MD∗; Ghasabeh, Mounes Aliyari MD∗; Wu, Qingxia MD∗; Tang, Hao MD∗; Khoshpouri, Pegah MD∗; Ameli, Sanaz MD∗; Habibabadi, Roya R. MD∗; Motaghi, Mina MD∗; Meyer, Christian F. MD, PhD†; Kamel, Ihab R. MD, PhD∗ Author Information From the ∗Russell H. Morgan Department of Radiology and Radiological Sciences †Division of Medical Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD. Received for publication March 11, 2021; accepted August 17, 2021. Correspondence to: Ihab R. Kamel, MD, PhD, Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Bayview Medical Center, Johns Hopkins Hospital 600 North Wolfe St, MRI 143, Baltimore, MD 21287 (e-mail: [email protected]). The authors declare no conflict of interest. Journal of Computer Assisted Tomography: 5/6 2022 - Volume 46 - Issue 3 - p 327-332 doi: 10.1097/RCT.0000000000001294 Buy Metrics Abstract Objective To predict early tumor response to transarterial chemoembolization (TACE) based on volumetric oil deposition on posttreatment computed tomography (CT) in patients with leiomyosarcoma liver metastases. Methods This retrospective lesion-by-lesion based study included 32 lesions. The volumetric percent enhancing tumor on pre-TACE and 1-month post-TACE venous phase magnetic resonance imaging (MRI), and the percent oil deposition on CT 1 day after TACE were calculated. The predicted post-TACE enhanced percentage was computed by subtracting percent oil deposition from baseline percent enhanced. Results Mean percentage of viable tumor on pre-TACE MRI was 90.6% ± 9.3%. Mean oil deposition was calculated as 51.4% ± 26.2%. Mean percentage of measured residual tumor enhancement 1 month after TACE was 58.3% ± 27%, which correlates with predicted enhancement percentage of 43.9% ± 25.1% (r = 0.72, P < 0.001). A threshold of 35.5% for enhancement reduction was determined to predict tumor response with an accuracy of 78.1%. Conclusion Volumetric oil deposition on CT can predict residual enhancement on post-TACE MRI. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.