Abdominopelvic Imaging: GastrointestinalClinical Importance of Incidentally Detected Hyperenhancing Liver Observations on Portal Venous Phase Computed Tomography in Patients Without Known Malignancy or Liver DiseaseCorwin, Michael T. MD∗; DiGeronimo, Ryan T. MD∗; Navarro, Shannon M. MD∗; Fananapazir, Ghaneh MD∗; Wilson, Machelle PhD†; Loehfelm, Thomas W. MD, PhD∗Author Information From the ∗Department of Radiology, University of California, Davis Medical Center, Sacramento †Department of Public Health Sciences, University of California, Davis, Davis, CA. Received for publication October 7, 2020; accepted January 20, 2021. Correspondence to: Michael T. Corwin, MD, University of California, Davis Medical Center, Department of Radiology, 4860 Y St, Suite 3100 Sacramento, CA 95817 (e-mail: [email protected]). The authors declare no conflict of interest. The project described was supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through grant number UL1 TR001860. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Journal of Computer Assisted Tomography: 7/8 2021 - Volume 45 - Issue 4 - p 516-521 doi: 10.1097/RCT.0000000000001154 Buy Metrics Abstract Objective The aim of the study was to determine the prevalence of clinically important masses among incidental hyperenhancing liver observations on portal venous phase computed tomography (CT) in patients without known malignancy or liver disease. Methods Retrospective search of portal venous phase CTs was performed to identify hyperenhancing liver observations in patients without cancer or liver disease. Observations were assigned a morphology of homogeneous, hemangioma, or heterogeneous. The reference standard was pathology (n = 2), liver protocol CT/magnetic resonance imaging (n = 40), follow-up portal venous phase CT for 2 years or more (n = 81), or clinical follow-up for 5 years or more (n = 107). Results There were no clinically important masses among 83 observations with homogeneous morphology or 110 with hemangioma morphology. There were 2 clinically important masses (1 hepatocellular carcinoma and 1 hepatic adenoma) among 37 (5.4%) heterogeneous morphology observations. Conclusions Incidental hyperenhancing liver observations on portal venous phase CT with homogeneous or typical hemangioma morphology in patients without known cancer or liver disease are highly likely benign. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.