THORACIC IMAGINGComputed Tomography Angiography–Based Pulmonary Artery Volumetry as a Diagnostic Tool for Pulmonary HypertensionCassady, Steven James MD∗; Mills-Robertson, Kweku BS†; Deepak, Janaki MD∗; Hossain, Rydhwana MD†Author Information From the ∗Department of Pulmonary & Critical Care Medicine †Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD. Received for publication February 28, 2020; accepted June 2, 2020. Correspondence to: Steven James Cassady, MD, Department of Pulmonary & Critical Care Medicine, University of Maryland School of Medicine, 110 S. Paca Street, 2nd Floor, Baltimore, MD 21201 (e-mail: [email protected]). The authors declare no conflict of interest. Journal of Computer Assisted Tomography: 9/10 2020 - Volume 44 - Issue 5 - p 681-686 doi: 10.1097/RCT.0000000000001082 Buy Metrics Abstract Objectives We evaluated use of three-dimensional pulmonary artery volumes derived from computed tomography pulmonary angiography (CTPA) in a group with pulmonary hypertension (PH) compared with healthy controls as a tool for the diagnosis of PH. Methods Retrospective analysis was performed of 40 CTPA scans obtained within 90 days of right heart catheterization demonstrating PH. The CTPA scans of 40 age- and sex-matched patients without cardiopulmonary disease were used as comparison. Diameters and volumes of the pulmonary arteries were compared. Results Adjusted total volume of the main, right, and left proximal pulmonary arteries (PAvol) demonstrated area under the curve of 0.918 (95% confidence interval, 0.860–0.975) for detection of PH, comparable to main pulmonary artery diameter measurement. Area under the curve values for PAvol were higher in subgroups divided by sex and PH severity. Conclusions Volumetric analysis of the proximal pulmonary arteries using CTPA is a promising diagnostic tool for PH in a real-world cohort. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.