NeuroradiologyImaging of Fulminant Demyelinating Disorders of the Central Nervous SystemRazek, Ahmed Abdel Khalek Abdel MD*; Elsebaie, Nermeen A. MD†Author Information From the *Department of Diagnostic Radiology, Mansoura Faculty of Medicine, Mansoura †Department of Radiology, Alexandria Faculty of Medicine, Alexandria, Egypt. Received for publication December 25, 2019; accepted January 2, 2020. Correspondence to: Ahmed Abdel Khalek Abdel Razek, MD, Department of Diagnostic Radiology, Mansoura Faculty of Medicine, 60 Elgomheryia St, Mansoura, Egypt 3512 (e-mail: firstname.lastname@example.org); Nermeen A. Elsebaie, MD, Department of Diagnostic Radiology, Alexandria Faculty of Medicine, Shamplion St, Alexandria, Egypt 21131 (e-mail: email@example.com; firstname.lastname@example.org). The authors declare no conflict of interest. Journal of Computer Assisted Tomography: March/April 2020 - Volume 44 - Issue 2 - p 248-254 doi: 10.1097/RCT.0000000000000997 Buy Metrics Abstract We aim to review the imaging appearance of fulminant demyelinating disorders of central nervous system that have different pathological features, clinical course, clinical features, and imaging findings different from classic multiple sclerosis. Routine magnetic resonance imaging (MRI) can help in accurate localization of the lesions, detection of associated lesions, and monitoring of these patients. Advanced MRI combined with routine MRI can aid in differentiation fulminant demyelinating lesions from simulating malignancy. Tumefactive demyelination lesions are located in supratentorial white matter mainly frontal and parietal regions with incomplete rim enhancement. Baló concentric sclerosis shows characteristic concentric onion skin appearance. Schilder disease is subacute or acute demyelinating disorders with one or more lesions commonly involving the centrum semiovale. Marburg disease is the most severe demyelinating disorder with diffuse infiltrative lesions and massive edema involving both the cerebral hemisphere and brain stem. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.