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Assessing the Relationship Between American Heart Association Atherosclerotic Cardiovascular Disease Risk Score and Coronary Artery Imaging Findings

Li, Ying MD, PhD*†; Zhu, Guangming MD, PhD*; Ding, Victoria MS; Jiang, Bin MD, PhD*; Ball, Robyn L. PhD; Ahuja, Neera MD§; Rodriguez, Fatima MD, MPH; Fleischmann, Dominik MD; Desai, Manisha PhD; Saloner, David PhD#; Saba, Luca MD**; Wintermark, Max MD, MAS*; Hom, Jason MD§

Journal of Computer Assisted Tomography: November/December 2018 - Volume 42 - Issue 6 - p 898–905
doi: 10.1097/RCT.0000000000000823
Cardiovascular Applications of Dual Energy CT

Objective The aim of this study was to characterize the relationship between computed tomography angiography imaging characteristics of coronary artery and atherosclerotic cardiovascular disease (ASCVD) score.

Methods We retrospectively identified all patients who underwent a coronary computed tomography angiography at our institution from December 2013 to July 2016, then we calculated the 10-year ASCVD score. We characterized the relationship between coronary artery imaging findings and ASCVD risk score.

Results One hundred fifty-one patients met our inclusion criteria. Patients with a 10-year ASCVD score of 7.5% or greater had significantly more arterial segments showing stenosis (46.4%, P = 0.008) and significantly higher maximal plaque thickness (1.25 vs 0.53, P = 0.001). However, among 56 patients with a 10-year ASCVD score of 7.5% or greater, 30 (53.6%) had no arterial stenosis. Furthermore, among the patients with a 10-year ASCVD score of less than 7.5%, 24 (25.3%) had some arterial stenosis.

Conclusions There is some concordance but not a perfect overlap between 10-year ASCVD risk scores and coronary artery imaging findings.

From the *Department of Radiology, Neuroradiology Section, Stanford University School of Medicine, Palo Alto, CA;

Department of Neurology, PLA Army General Hospital, Beijing, China;

Department of Medicine, Quantitative Sciences Unit, and

§Department of Medicine, Stanford University School of Medicine;

Division of Cardiovascular Medicine, Stanford University; and

Department of Radiology, Cardiovascular Imaging Section, Stanford University School of Medicine, Palo Alto; and

#Department of Radiology, University of California San Francisco, San Francisco, CA; and

**Dipartimento di Radiologia, Azienda Ospedaliero Universitaria di Cagliari, Cagliari, Italy.

Received for publication July 11, 2018; accepted September 8, 2018.

Correspondence to: Max Wintermark, MD, MAS, Neuroradiology Section, Department of Radiology, Stanford University School of Medicine, 300 Pasteur Dr, Grant S047, Stanford, CA 94305 (e-mail:

M.W. and J.H. are co–senior authors.

The authors declare no conflict of interest.

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