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Survival Associations Using Perfusion and Diffusion Magnetic Resonance Imaging in Patients With Histologic and Genetic Defined Diffuse Glioma World Health Organization Grades II and III

Latysheva, Anna, MD*; Eeg Emblem, Kyrre, PhD; Server, Andrés, MD, PhD*; Brandal, Petter, MD, PhD; Meling, Torstein R., MD§; Pahnke, Jens, MD, PhD∥¶#**; Hald, John K., MD, PhD

Journal of Computer Assisted Tomography: September/October 2018 - Volume 42 - Issue 5 - p 807–815
doi: 10.1097/RCT.0000000000000742
Neuroradiology

Objective According to the new World Health Organization 2016 classification for tumors of the central nervous system, 1p/19q codeletion defines the genetic hallmark that differentiates oligodendrogliomas from diffuse astrocytomas. The aim of our study was to evaluate whether relative cerebral blood volume (rCBV) and apparent diffusion coefficient (ADC) histogram analysis can stratify survival in adult patients with genetic defined diffuse glioma grades II and III.

Methods Sixty-seven patients with untreated diffuse gliomas World Health Organization grades II and III and known 1p/19q codeletion status were included retrospectively and analyzed using ADC and rCBV maps based on whole-tumor volume histograms. Overall survival and progression-free survival (PFS) were analyzed by using Kaplan-Meier and Cox survival analyses adjusted for known survival predictors.

Results Significant longer PFS was associated with homogeneous rCBV distribution–higher rCBVpeak (median, 37 vs 26 months; hazard ratio [HR], 3.2; P = 0.02) in patients with astrocytomas, and heterogeneous rCBV distribution–lower rCBVpeak (median, 46 vs 37 months; HR, 5.3; P < 0.001) and higher rCBVmean (median, 44 vs 39 months; HR, 7.9; P = 0.003) in patients with oligodendrogliomas. Apparent diffusion coefficient parameters (ADCpeak, ADCmean) did not stratify PFS and overall survival.

Conclusions Tumors with heterogeneous perfusion signatures and high average values were associated with longer PFS in patients with oligodendrogliomas. On the contrary, heterogeneous perfusion distribution was associated with poor outcome in patients with diffuse astrocytomas.

From the Departments of *Radiology,

Diagnostic Physics,

Oncology,

§Neurosurgery, and

Pathology, Oslo University Hospital—Rikshospitalet;

Faculty of Medicine, University of Oslo, Oslo, Norway;

#University of Lübeck, LIED, Lübeck;

**Institute of Plant Biochemistry, Halle, Germany.

Received for publication October 24, 2017; accepted January 16, 2018.

Correspondence to: Anna Latysheva, MD, Department of Radiology, Oslo University Hospital—Rikshospitalet, Postboks 4950 Nydalen, 0424 Oslo, Norway (e-mail: alatysheva@ous-hf.no).

The authors declare no conflict of interest.

Former presentation: Part of the results was presented in an abstract at the American Society of Neurorehabilitation in 2017.

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