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Solid Papillary Carcinoma of the Breast: Magnetic Resonance Mammography, Digital Mammography, and Ultrasound Findings

You, Chao, MD*†; Peng, Weijun, MD*†; Shen, Xuxia, MD†‡; Zhi, Wenxiang, MD†§; Yang, Wentao, MD†‡; Gu, Yajia, MD*†

Journal of Computer Assisted Tomography: September/October 2018 - Volume 42 - Issue 5 - p 771–775
doi: 10.1097/RCT.0000000000000745
Breast Imaging

Background The aim of this study was to investigate the MR mammography (MRM), digital mammography (DM), and ultrasound (US) findings of solid papillary carcinoma (SPC) of breast and to raise awareness of this rare breast tumor.

Material and Methods Thirty patients diagnosed with breast SPC (age range, 21–72; mean age, 60.27 years) from January 2013 to August 2015 were enrolled. Their clinical presentation and MRM, DM, and US findings were retrospectively reviewed. All patients underwent both MRM and US, and 20 of them underwent DM. The research primarily investigated MRM features correlated with clinicopathological characteristics.

Results Of all the patients, 13 were pure SPC in suit, whereas 17 were microinvasive SPC. The detection rates of US, DM, and magnetic resonance imaging for SPC were 30%, 50%, and 100%, respectively, and there were no specific imaging features on DM and US. The most common MRM appearances were located in the retroareolar area (16/30, 53.34%) with T2WI hyperintensity (24/30, 80%) and ductal ectasia (18/30, 60%). Non–mass enhancement of a linear or segmental distribution (17/18, 94.44%) together with clumped enhancement (12/18, 66.66%) and mass with a rim (6/12, 50%) or heterogeneous (6/12, 50%) enhancement were 2 of the typical enhancement features of SPC. Compared with pure SPC, SPC with microinvasive showed larger size of the lesion (t = 1.083, P = 0.026).

Conclusion Although SPC was difficult to detect in both DM and US, MRM gave better detection of this rare tumor. The MRM characteristics of SPC were distinct and highly similar to its clinicopathological features.

From the *Department of Radiology, Fudan University Cancer Center;

Department of Oncology, Shanghai Medical College, Fudan University;

Department of Pathology, and

§Department of Ultrasound, Fudan University Cancer Center, Shanghai, China.

Received for publication December 3, 2017; accepted February 7, 2018.

Correspondence to: Yajia Gu, MD, Department of Radiology, Fudan University Cancer Center, and Department of Oncology, Shanghai Medical College, Fudan University, No. 270, Dongan Road, 200032 Shanghai, China (e-mail: cjr.guyajia@vip.163.com).

The authors declare no conflict of interest.

This project was supported (in part) by the grants from the National Key Research and Development Programme of China (grant no. 2016YFC1303003).

Author contributions: All authors contributed fundamentally to this study and participated sufficiently to take public responsibility for its content. Chao You and Weijun Peng collected the data and were responsible for quality control of data and interpretation. Xuxia Shen and Wentao Yang reviewed all the pathologic specimens collected the pathologic images. Wenxiang Zhi collected the ultrasound images. Weijun Peng reviewed the manuscript. Yajia Gu reviewed and edited the manuscript. Publication is approved by all authors.

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