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Evaluation of Modified Look-Locker Inversion Recovery and Arrhythmia-Insensitive Rapid Cardiac T1 Mapping Pulse Sequences in Cardiomyopathy Patients

Robison, Sean, MBBS*; Hong, KyungPyo, PhD; Kim, Daniel, PhD; Lloyd, Rachel, MBBS; Ramchand, Jay, MBBS‡§; Hornsey, Emma, BAppSc*; Srivastava, Piyush, MBBS‡§; Smith, Gerard, MBBS*∥; Kearney, Leighton, PhD‡§; Lim, Ruth, MBBS*∥

Journal of Computer Assisted Tomography: September/October 2018 - Volume 42 - Issue 5 - p 732–738
doi: 10.1097/RCT.0000000000000746
Cardiovascular and Thoracic Imaging

Objective The aim of this study was to compare the performance of arrhythmia-insensitive rapid (AIR) and modified Look-Locker inversion recovery (MOLLI) T1 mapping in patients with cardiomyopathies.

Methods In 58 patients referred for clinical cardiac magnetic resonance imaging at 1.5 T, we compared MOLLI and AIR native and postcontrast T1 measurements. Two readers independently analyzed myocardial and blood T1 values. Agreement between techniques, interreader agreement per technique, and intrascan agreement per technique were evaluated.

Results The MOLLI and AIR T1 values were strongly correlated (r 2 = 0.98); however, statistically significantly different T1 values were derived (bias 80 milliseconds, pooled data, P < 0.01). Both techniques demonstrated high repeatability (MOLLI, r 2 = 1.00 and coefficient of repeatability [CR] = 72 milliseconds; AIR, r 2 = 0.99 and CR = 184.2 milliseconds) and produced high interreader agreement (MOLLI, r 2 = 1.00 and CR = 51.7 milliseconds; AIR, r 2 = 0.99 and CR = 183.5 milliseconds).

Conclusions Arrhythmia-insensitive rapid and MOLLI sequences produced significantly different T1 values in a diverse patient cohort.

From the *Department of Radiology, Austin Hospital, Austin Health (Department Affiliated With The University of Melbourne, Melbourne Medical School), Heidelberg, Victoria, Australia;

Department of Radiology, Northwestern University, Chicago, IL; and

Department of Cardiology, St Vincent's Hospital, Melbourne;

§Department of Medicine, The University of Melbourne, Austin Health, Heidelberg; and

Departments of Radiology and Surgery, The University of Melbourne, Parkville, Victoria, Australia.

Received for publication August 30, 2017; accepted February 12, 2018.

Correspondence to: Sean Robison, MBBS, PO Box 3024, Manuka, Australian Capital Territory, Australia 2603 (e-mail:

Support was provided by the National Institutes of Health (R01HL116895, R01HL138578, R21EB024315, R21AG055954).

The authors declare no conflict of interest.

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