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Gynecological Lymphoma

A Case Series and Review of the Literature

Slonimsky, Einat, MD*; Korach, Jacob, MD; Perri, Tamar, MD; Davidson, Tima, MD; Apter, Sara, MD*; Inbar, Yael, MD*

Journal of Computer Assisted Tomography: May/June 2018 - Volume 42 - Issue 3 - p 435–440
doi: 10.1097/RCT.0000000000000709
Abdominal Imaging

Objective The aim of the study was to evaluate the radiological characteristics of gynecological lymphoproliferative disease (LPD) and specific imaging features that may suggest the diagnosis.

Methods Two readers conducted a retrospective evaluation of imaging studies of 13 female patients presenting with a gynecological LPD. A literature review was also performed.

Results Of the 13 evaluated women, 9 had ovarian involvement, 3 had cervical involvement, and 1 had uterine involvement. The most common lesion characteristics were homogenous masses (11), with mild contrast enhancement (9), followed by soft-tissue necrosis (4), prominent blood vessels displaced by the lesions (4), linear arrangement of cysts at the periphery of the ovaries (3), and “touching” ovaries in all cases of bilateral ovarian involvement.

Conclusions A solid large homogeneous mass with mild contrast enhancement should alert the radiologist to the possibility of the differential diagnosis of LPD. Radiologists should be “the gatekeepers” by raising this possibility to avoid unnecessary surgery and enable appropriate treatment.

From the Departments of *Diagnostic Imaging,

Gynecologic Oncology, and

Nuclear Medicine, The Chaim Sheba Medical Center, Affiliated to the Tel-Aviv University Sackler School of Medicine, Tel Aviv, Israel.

Received for publication August 29, 2017; accepted October 23, 2017.

Correspondence to: Einat Slonimsky, MD, Department of Imaging, Sheba Medical Center, 52621, Tel Hashomer, Ramat Gan, Israel (e-mail:

The authors declare no conflict of interest.

The study was approved by the local ethics committee. Informed consent was waived because of the retrospective extraction of data from the electronic records and the picture archiving and communication system.

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