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Preliminary Results: Can Dual-Energy Computed Tomography Help Distinguish Cardiogenic Pulmonary Edema and Acute Interstitial Lung Disease?

Takeuchi, Hitoshi, MD*†; Suzuki, Shigeru, MD; Machida, Haruhiko, MD; Ishikawa, Takuya, MD; Ueno, Eiko, MD

Journal of Computer Assisted Tomography: January/February 2018 - Volume 42 - Issue 1 - p 39–44
doi: 10.1097/RCT.0000000000000643
Thoracic Imaging

Objective We compared iodine concentration in pulmonary ground-glass opacity on iodine density images of contrast-enhanced chest dual-energy computed tomography (DECT) between patients with cardiogenic pulmonary edema (CPE) and acute interstitial lung disease (AILD).

Methods Five of 12 patients who underwent contrast-enhanced chest DECT to exclude pulmonary embolism were clinically diagnosed with CPE and 7, with AILD. We compared the mean CT value on monochromatic images at 65 keV and iodine concentration on iodine density images between the affected and normal areas.

Results The mean iodine concentrations were comparable between the affected and normal areas (P = 0.3048) in patients with CPE and were significantly higher in the affected than in the normal areas in those with AILD (P < 0.0001).

Conclusions Measurement of iodine concentration in pulmonary ground-glass opacity of contrast-enhanced chest DECT has the potential to help distinguish CPE and AILD.

From the *Department of Radiology, Tokyo Metropolitan Tama Medical Center; and †Department of Radiology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.

Received for publication December 18, 2016; accepted March 14, 2017.

Correspondence to: Hitoshi Takeuchi, MD, Department of Radiology, Fukujuji Hospital, 3-1-24 Matsuyama, Kiyose-shi, Tokyo, 204-8522, Japan (e-mail:

The authors declare no conflict of interest.

Our institutional ethics committee approved this retrospective study, and all patients provided written informed consent.

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