Abdominal ImagingEarly Response of Hepatocellular Carcinoma to Chemoembolization Volume Computed Tomography Liver Perfusion Imaging as a Short-Term Response PredictorSu, Tian-Hao MD; He, Wen MD; Jin, Long MD; Chen, Guang MD; Xiao, Guo-Wen MDAuthor Information From the Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Xicheng District, Beijing, China. Received for publication June 10, 2016; accepted June 22, 2016. Correspondence to: Wen He, Beijing Friendship Hospital, Capital Medical University, 95 YongAn Road, Xicheng District, Beijing 100050, China (e-mail: email@example.com); Long Jin, Beijing Friendship Hospital, Capital Medical University, 95 YongAn Road, Xicheng District, Beijing 100050, China (e-mail: firstname.lastname@example.org). Source of funding: none. The authors declare no conflict of interest. Journal of Computer Assisted Tomography: March/April 2017 - Volume 41 - Issue 2 - p 315-320 doi: 10.1097/RCT.0000000000000511 Buy Metrics Abstract Objective The aim of this study was to investigate the efficacy of lesion-oriented whole-liver computed tomography (CT) perfusion for predicting transarterial chemoembolization early treatment response in patients with hepatocellular carcinoma (HCC). Methods Volume helical shuttle CT perfusion imaging on the whole liver was prospectively performed on 39 patients with 46 independent HCC lesions before target-selected chemoembolization. The therapeutic effects were assessed: responder group included lesions with a complete and partial response, whereas the nonresponder group contained stable and progressive disease. The perfusion parameter value comparison between 2 groups and receiver operating characteristic analyses were performed. Results The responders demonstrated higher hepatic arterial perfusion (HAP) and hepatic arterial perfusion index (HAPI) and lower hepatic portal perfusion (HPP) compared with the nonresponders among the 34 lesions without Vp3 or Vp4 portal vein thrombosis. In addition, HAP and HAPI had good prognostic values. Conclusions Whole-liver CT perfusion allows for hemodynamic evaluation of HCC lesions. The HAP, HAPI, and hepatic portal perfusion values may be useful predictors of short-term therapeutic response after transarterial chemoembolization. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.