The aim of this study was to discuss the correlation of quantitative dynamic contrast-enhanced magnetic resonance imaging (QDCE-MRI) at 3.0-T magnetic resonance and histopathology for pancreatic ductal adenocarcinoma (PDA).
Twenty-three patients with histopathologically proven PDA were included in this study after 75 cases of suspected pancreatic tumors had been performed by QDCE-MRI. The quantitative kinetic parameters analyzed by 2-compartment and 3-compartment models were calculated automatically, which included the volume transfer constant of the contrast agent, the rate constant (Kep), the volume as a percentage of the extravascular extracellular leakage space, the time of arrival of contrast agent, the time of peaking of contrast agent, the maximum slope of signal intensity ascent, and the contrast enhancement ratio. According to magnetic resonance images, tissue section were selected and stained for evaluating tumor differentiation, tumor fibrosis, tumor microvessel density, the expression of tumor vascular endothelial growth factor (VEGF) and Ki67. Subsequently, the relationship between the parameters of QDCE-MRI and histopathology of PDA was analyzed.
The tumor Kep and extravascular extracellular leakage space showed a statistically significant correlation with tumor fibrosis; the tumor volume transfer constant of the contrast agent 2-compartment showed a statistically significant correlation with the expressions of tumor VEGF; and the tumor Kep, maximum slope of signal intensity ascent, and contrast enhancement ratio showed a statistically significant correlation with the expression of tumor Ki67.
The parameters of QDCE-MRI of PDA can be used to evaluate the degrees of tumor fibrosis and the expressions of VEGF and Ki67.
From the *Department of Radiology, Fudan University Shanghai Cancer Center, and †Department of Oncology, Shanghai Medical College, Fudan University, Shanghai; and ‡Department of Radiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
Received for publication July 8, 2014; accepted September 18, 2014.
Reprints: Zhengrong Zhou, MD, PhD, Department of Radiology, Cancer Hospital, Fudan University, No. 270, Dong An Rd, Shanghai 200032, China (e-mail: firstname.lastname@example.org).
This project was funded by Shanghai Important Technological Subject Fund of China (no. 08411954400) and Program for Shanghai Outstanding Academic Leader of China (no. 11XD1401600).
The authors declare no conflict of interest.