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Evaluation of Hepatic Fibrosis Using Intravoxel Incoherent Motion in Diffusion-Weighted Liver MRI

Yoon, Jeong Hee MD; Lee, Jeong Min MD; Baek, Jee Hyun MD; Shin, Cheong-il MD; Kiefer, Berthold PhD; Han, Joon Koo MD; Choi, Byung-Ihn MD

Journal of Computer Assisted Tomography: January/February 2014 - Volume 38 - Issue 1 - p 110–116
doi: 10.1097/RCT.0b013e3182a589be
Abdominal Imaging

Objectives To determine whether intravoxel incoherent motion (IVIM)–diffusion-weighted image (DWI)–derived parameters showed better diagnostic performance than the apparent diffusion coefficient (ADCtotal) for the evaluation of hepatic fibrosis (HF).

Methods This retrospective study was approved by institutional review board, and informed consent was waived. Fifty-five patients with chronic liver disease who had undergone IVIM-DWI using 8 b-values at 3 T were included. True diffusion coefficient (D t), pseudo-diffusion coefficient (D p), perfusion fraction (f), and ADCtotal were calculated. Receiver operating characteristic analysis was performed for all parameters for the HF staging.

Results All parameters showed a significant correlation with the HF stages (−0.31 to −0.72, P < 0.05). All parameters were significantly higher in F0 to F1 than in F4 (P < 0.05). The D p showed better performance than the ADCtotal in differentiating significant HF (≥F2) from F0 to F1.

Conclusions The IVIM-derived parameters and ADCtotal showed significant correlation with HF. The D p showed better diagnostic performance for differentiating significant HF than did ADCtotal.

From the *Department of Radiology, Seoul National University Hospital; and †Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Korea; and ‡Siemens Healthcare, Erlangen, Germany.

Received for publication April 2, 2013; accepted July 16, 2013.

Reprints: Jeong Min Lee, MD, Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea (e-mail:

B.K. is an employee of Siemens Healthcare.

The remaining authors declare no conflict of interest.

Copyright © 2014 Wolters Kluwer Health, Inc. All rights reserved.