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Rapid Assessment of Liver Volumetry by a Novel Automated Segmentation Algorithm

Zahel, Tina MD; Wildgruber, Moritz MD, PhD; Ardon, Roberto PhD; Schuster, Tibor PhD; Rummeny, Ernst J. MD; Dobritz, Martin MD

Journal of Computer Assisted Tomography: July/August 2013 - Volume 37 - Issue 4 - p 577–582
doi: 10.1097/RCT.0b013e31828f0baa
Abdominal Imaging

Objective This study aimed to evaluate a novel segmentation software for automated liver volumetry and segmentation regarding segmentation speed and interobserver variability.

Methods Computed tomographic scans of 20 patients without underlying liver disease and 10 patients with liver metastasis from colorectal cancer were analyzed by a novel segmentation software. Liver segmentation was performed after manual placement of specific landmarks into 9 segments according to the Couinaud model as well as into 4 segments, the latter being import for surgery planning. Time for segmentation was measured and the obtained segmental and total liver volumes between the different readers were compared calculating intraclass correlations (ICCs). Volumes of liver tumor burden were evaluated similarly.

Results Liver segmentation could be performed rapidly 3 minutes or less. Comparison of total liver volumes revealed a perfect ICC of greater than 0.997. Segmental liver volumes within the 9-part segmentation provided fair to moderate correlation for the left lobe and good to excellent correlations for the right lobe. When applying a 4-part segmentation relevant to clinical practice, strong to perfect agreement was observed. Similarly tumor volumes showed perfect ICC (>0.998).

Conclusions Rapid determination of total and segmental liver volumes can be obtained using a novel segmentation software suitable for daily clinical practice.

From the *Department of Diagnostic and Interventional Radiology, Klinikum Rechts der Isar, Technische Universität München, München, Germany; †Medisys Research Laboratory, Philips Medical Systems, Paris, France; and ‡Institute for Medical Statistics and Epidemiology, Klinikum Rechts der Isar, Technische Universität München, München, Germany.

Received for publication December 27, 2012; accepted February 25, 2013.

Reprints: Moritz Wildgruber, MD, PhD, Department of Radiology, Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, D-81675 München, Germany (e-mail:

Dr Ardon is an employee of Philips Medical Systems. The other authors declare no conflict of interest.

Dr Zahel and Dr Wildgruber contributed equally to this work.

Copyright © 2013 Wolters Kluwer Health, Inc. All rights reserved.