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Contrast Enhancement During Hepatic Computed Tomography: Effect of Total Body Weight, Height, Body Mass Index, Blood Volume, Lean Body Weight, and Body Surface Area

Kidoh, Masafumi MD; Nakaura, Takeshi MD; Oda, Seitaro MD; Namimoto, Tomohiro MD; Awai, Kazuo MD; Yoshinaka, Ichiro MD; Harada, Kazunori MD; Yamashita, Yasuyuki MD

Journal of Computer Assisted Tomography: March/April 2013 - Volume 37 - Issue 2 - p 159–164
doi: 10.1097/RCT.0b013e31827dbc08
Abdominal Imaging

Objective The objective of this study was to evaluate the effect of total body weight, height, body mass index, blood volume, lean body weight, and body surface area (BSA) on aortic and hepatic contrast enhancement during hepatic computed tomography (CT).

Methods We calculated the changes in the CT number per gram of iodine ((Δ Hounsfield units/g [ΔHU/g])) for the aorta and the liver during portal venous phase. We performed linear regression analyses between ΔHU/g and each of the body parameters.

Results ΔHU/g and BSA showed the strongest inverse correlation. The correlation coefficients for the aorta and liver were 0.70 and 0.68 for ΔHU/g and total body weight, 0.41 and 0.37 for height, 0.54 and 0.55 for body mass index, 0.68 and 0.59 for blood volume, 0.70 and 0.62 for lean body weight, and 0.71 and 0.68 for BSA, respectively (P < 0.001 for all).

Conclusion Our study supports the use of a protocol with iodine dose adjusted for the patient BSA.

From the *Diagnostic Radiology, Amakusa Medical Center; †Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto; ‡Department of Diagnostic Radiology, Hiroshima University, Hiroshima; and §Department of Surgery, Amakusa Medical Center, Kumamoto, Japan.

Received for publication April 4, 2012; accepted September 6, 2012.

Reprints: Masafumi Kidoh, MD, Diagnostic Radiology, Amakusa Medical Center, Kameba 854-1, Amakusa, Kumamoto 863-0046, Japan (e-mail:

The authors declare no conflicts of interest.

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