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A Novel Biphasic Oral Contrast Solution for Enterographic Studies

Algin, Oktay MD; Evrimler, Sehnaz MD; Ozmen, Evrim MD; Metin, Melike Ruşen MD; Ocakoglu, Gokhan PhD; Ersoy, Osman; Karaoglanoglu, Mustafa; Arslan, Halil

Journal of Computer Assisted Tomography: January/February 2013 - Volume 37 - Issue 1 - p 65–74
doi: 10.1097/RCT.0b013e318276b585
Abdominal Imaging

Purpose To compare the efficacy and patients’ tolerance of a new mixed biphasic oral contrast solution with routine biphasic oral contrast agent in magnetic resonance (MR) enterography (MRE).

Materials and Methods Thirty-seven patients (group 1) had MRE with the new mixture, whereas 14 patients (group 2) had MRE with biphasic oral contrast agent (lactulose). Magnetic resonance enterography images were evaluated by 2 experienced radiologists. Each intestinal segment was evaluated for luminal distension (LD), distinction from the surrounding tissue (wall conspicuity), and the confidence of radiologist for evaluation of the specified segment (radiological evaluation confidence). Comparisons between the 2 groups were performed using the Mann-Whitney U test. Interrater and intrarater agreement values were obtained. In addition, patients’ acceptability and tolerance were assessed.

Results The new mixture was more effective than the oral contrast agent used in group 2 for LD, wall conspicuity, and radiological confidence. The values of interrater and intrarater agreement in scoring LD, wall conspicuity, and radiological confidence were generally moderate.

Conclusion Our new mixture allowed good-quality enterographic images, and this solution was well tolerated by patients. In addition, this mixture is useful for evaluation of small bowels and colonic segments. We suggest the use of it for enterographic examinations.

From the Departments of *Radiology, and †Gastroenterology, Ataturk Training and Research Hospital, Bilkent, Ankara; and ‡ Department of Biostatistics, Uludag University, Medical Faculty, Bursa, Turkey.

Received for publication June 28, 2012; accepted September 19, 2012.

Reprints: Oktay Algin, MD, Department of Radiology, Ataturk Training and Research hospital, 06050, Ankara-Turkey (e-mail:

The authors have no financial disclosure. They declare that they have no conflicts of interest.

This study was presented as a scientific presentation at the 33rd National Radiology Congress, Antalya, Turkey, November 7–11, 2012.

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