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Computed Tomography and Magnetic Resonance Imaging of Adult Renal Cell Carcinoma Associated With Xp11.2 Translocation

Dang, Trien T. MD; Ziv, Etay MD, PhD; Weinstein, Stefanie MD; Meng, Maxwell V. MD; Wang, Zhen MD; Coakley, Fergus V. MD

Journal of Computer Assisted Tomography: November/December 2012 - Volume 36 - Issue 6 - p 669–674
doi: 10.1097/RCT.0b013e3182680182
Cardiothoracic Imaging

Objective This study aimed to report the computed tomography (CT) and magnetic resonance imaging (MRI) findings of renal cell carcinoma associated with Xp11.2 translocation in adults.

Methods We retrospectively identified 9 adults with renal cell carcinoma associated with Xp11.2 translocation who underwent baseline cross-sectional imaging with CT (n = 9) or MRI (n = 3). All available clinical, imaging, and histopathological records were reviewed.

Results Mean patient age was 24 years (range, 18–45 years). Eight of 9 cancers demonstrated imaging findings of hemorrhage or necrosis (n = 3), advanced stage disease (n = 2), or both (n = 3) at CT or MRI.

Conclusions The possibility of renal cell carcinoma associated with Xp11.2 translocation should be considered for a renal mass seen in a patient 45 years or younger, which demonstrates hemorrhage or necrosis or advanced stage disease at CT or MRI.

From the Departments of *Radiology and Biomedical Imaging and †Urology, University of California San Francisco, San Francisco, CA.

Received for publication April 13, 2012; accepted July 3, 2012.

Reprints: Fergus Coakley, MD, Department of Radiology Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, L340 Portland, OR 97239 (e-mail:

Dr Ziv was supported by T32 training grant 1 T32 EB001631 from the National Institute of Biomedical Imaging and Bioengineering.

The authors have no conflicts of interest.

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.