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Comparison of 320-Row Computed Tomography Coronary Angiography With Conventional Angiography for the Assessment of Coronary Artery Disease With Different Atherosclerotic Plaque Characteristics

Yang, Qing-Hui MD; Chen, Yan-Jun MD; Liu, Qian-Qian MD; Dong, Min MD; Wen, Liang MD; Song, Xiang MD; Lv, Yan-Jie MD; Gong, Ying-Zi MD; Li, Xue-Qi MD

Journal of Computer Assisted Tomography: November/December 2012 - Volume 36 - Issue 6 - p 646–653
doi: 10.1097/RCT.0b013e31826ab24a
Cardiothoracic Imaging

Objective The objective of this study was to compare the accuracy of 320-row computed tomography angiography (CTA) with conventional coronary angiography.

Methods Two hundred seventy-four patients with coronary artery disease who received both invasive coronary angiography and 320-row CTA were included. Stenosis of 50% or greater was considered obstructive.

Results In patient-based analysis, accuracy of CTA was 89.4%, with sensitivity of 94.6% and specificity of 54.3%. In segment-based analysis, the overall (4110 segments) accuracy of CTA was 90.7%, with sensitivity of 66.5% and specificity of 95.8%. For the segments with plaques (1191 segments), accuracy of CTA was 80.1%, with sensitivity of 83.5% and specificity of 77.0%. For segments with no plaque (2919 segments), accuracy of CTA was 95.0%, with sensitivity of 0.7% and specificity of 100.0%. For the segments with stents (110 segments), the accuracy of CTA was 86.4%.

Conclusions A 320-row CTA has potential to detect coronary lesions with soft and intermediate plaques.

Supplemental digital content is available in the text.

From the Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Heilongjiang, China.

Received for publication April 25, 2012; accepted July 19, 2012.

Reprints: Xue-Qi Li, MD, Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, No. 37 Yiyuan St, Harbin 150001, People’s Republic of China (e-mail:

The authors declare no conflict of interest.

Author contributions: Q.-H.Y. contributed to the experimental design performance, data analysis, and manuscript writing; Y.-J.C. and Q.-Q.L. contributed to the data collection and data analysis; M.D., X.S., Y.-Z.G., and L.W. contributed to the image collection. Y.-J.L. contributed to data analysis and manuscript revision. X.-Q.L. contributed to the experimental design and manuscript writing and revision. All authors had full access to all study data and had final responsibility for the decision to submit for publication. All have reviewed the manuscript and approved the final version for submission.

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Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.