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A Phantom Approach to Interscanner Comparability of Computed Tomographic Brain Perfusion Parameters

Mathys, Christian MD; Rybacki, Konrad MD; Wittsack, Hans-Jörg Dr. rer. nat.; Lanzman, Rotem Shlomo MD; Miese, Falk Roland MD; Macht, Stephan MD; Eicker, Sven MD; zu Hörste, Gerd Meyer MD; Antoch, Gerald MD; Turowski, Bernd MD

Journal of Computer Assisted Tomography: November/December 2012 - Volume 36 - Issue 6 - p 732–738
doi: 10.1097/RCT.0b013e31826801df

Objective This study aimed to create a phantom, which allows reproducible computed tomography perfusion experiments, and to identify the influence of contrast bolus configuration, scan parameters, and scanner hardware on the calculation of perfusion parameters.

Methods A discoid perfusion phantom with centrifugally directed flow was constructed. Brain parenchyma was simulated by inert polyoxymethylene spheres. Repeated measurements were performed with variations of the above-mentioned factors, and their effects on perfusion results were analyzed.

Results Calculated flow values measured during experiments were reproducible and showed good correlation with the true flow (R = 0.995, P < 0.01). Tube voltage, injection rate of the contrast agent, the mathematical perfusion algorithm, and the hardware of the scanner hardware had a reproducible influence on calculated perfusion results.

Conclusions In the long term, perfusion phantoms might be helpful in identifying hardware-specific and protocol-related factors of different computed tomography scanners to improve comparability of different scanners and scanning protocols.

From the Departments of *Diagnostic and Interventional Radiology, †Neurosurgery, and ‡Neurology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.

Received for publication May 9, 2012; accepted July 3, 2012.

Reprints: Christian Mathys, MD, Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, D-40225, Düsseldorf, Germany (e-mail:

The authors did not receive funding for this study.

The authors have no conflicts of interest.

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.