Development and Validation of a Practical Lower-Dose-Simulation Tool for Optimizing Computed Tomography Scan ProtocolsYu, Lifeng PhD; Shiung, Maria BA; Jondal, Dayna BA; McCollough, Cynthia H. PhDJournal of Computer Assisted Tomography: July/August 2012 - Volume 36 - Issue 4 - p 477–487 doi: 10.1097/RCT.0b013e318258e891 CT and Digital Techniques Abstract Author Information Objective The objective of this study was to develop and validate a novel noise insertion method that can accurately simulate lower-dose images from existing standard-dose computed tomography (CT) data. Methods The noise insertion method incorporates the effects of the bowtie filter, automatic exposure control, and electronic noise. We validated this tool using both phantom and patient studies. The phantom study compared simulated lower-dose images with the actually acquired lower-dose images. The patient studies included 105 pediatric and 24 adult CT body examinations. Results The noise level in the simulated images was within 3.2% of the actual lower-dose images in phantom experiments. Noise power spectrum also demonstrated excellent agreement. For the patient examinations, a mean difference of noise level between 2.0% and 9.7% was observed for simulated dose levels between 75% and 30% of the original dose. Conclusions An accurate technique for simulating lower-dose CT images was developed and validated, which can be used to retrospectively optimize CT protocols. From the Department of Radiology, Mayo Clinic, Rochester, MN. Received for publication February 9, 2012; accepted April 4, 2012. Reprints: Lifeng Yu, PhD, 200 First St SW, Rochester, MN 55905 (e-mail: firstname.lastname@example.org). This work was supported in part by a research grant from Thrasher Research Foundation. The authors have no conflict of interest to report. Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.