Serial 3-Dimensional Volumetric Computed Tomography Evaluation of Lung Cancer Growth Rate in Patients With Chronic Obstructive Pulmonary Disease FindingsTanimoto, Daigo MD, PhD*; Ito, Katsuyoshi MD, PhD*; Tamada, Tsutomu MD, PhD*; Higaki, Atsushi MD*; Kanki, Akihiko MD*; Sato, Tomohiro MD*; Noda, Yashufumi MD*; Higashi, Hiroki MD*; Nakata, Masao MD, PhD†Journal of Computer Assisted Tomography: March/April 2012 - Volume 36 - Issue 2 - p 181–186 doi: 10.1097/RCT.0b013e3182483c32 Thoracic Imaging Abstract Author Information Purpose The objectives of this study were to compare volume doubling time (VDT) of lung cancer with chronic obstructive pulmonary disease (COPD) findings with that without COPD findings using serial 3-dimensional (3D) volumetric computed tomography (CT) and to investigate the association between VDT and COPD findings. Methods This study included 45 patients with surgically diagnosed non–small cell lung cancer with serial preoperative follow-up CT. Volume doubling time of the nodule was calculated by using 3D volumetric computer software. Results Volume doubling time of lung cancer with COPD findings (n = 26) tended to be shorter than that without COPD findings (n = 19) (998 ± 2178 vs 2226 ± 6748 days; P = 0.066). Among COPD findings, severity and pattern of emphysema were significantly correlated with VDT (P < 0.001). Conclusions Volume doubling time of lung cancer with COPD findings on 3D volumetric CT tended to be shorter than that of lung cancer without COPD findings. Severe or paraseptal emphysema may be associated with short VDT of lung cancer with COPD findings. From the Department of *Radiology, and †Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Kawasaki Medical School, Kurashiki City, Okayama, Japan. Received for publication October 31, 2011; accepted December 24, 2011. Reprints: Daigo Tanimoto, Department of Radiology, Kawasaki Medical School, 577 Matsushima, Kurashiki City, Okayama 701-0192, Japan (e-mail: email@example.com). The authors report no conflicts of interest. © 2012 Lippincott Williams & Wilkins, Inc.