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Gadobenate Dimeglumine–Enhanced Liver Magnetic Resonance Imaging: Value of Hepatobiliary Phase for the Detection of Focal Liver Lesions

Fu, Guo-li MD*; Du, Yong MD*; Zee, Chi-shing MD; Yang, Han-feng MD*; Li, Yang MD*; Duan, Ru-gang MD*; Zeng, Nan-lin MD*; Xiao, Dong-Mei MD*

Journal of Computer Assisted Tomography: January/February 2012 - Volume 36 - Issue 1 - p 14–19
doi: 10.1097/RCT.0b013e31823dc139
Abdominal Imaging

Objective The objective of the study was to determine the value of addition of hepatobiliary phase to dynamic gadobenate dimeglumine (Gd-BOPTA)–enhanced imaging for the detection of focal liver lesions (nodules with diameter ≤3.0 cm).

Methods Routine nonenhanced magnetic resonance images were obtained in 25 patients with focal liver lesions suggested by ultrasonography and/or computed tomography.

T1-weighted dynamic gradient-echo images were acquired immediately and 100 minutes after bolus injection of Gd-BOPTA. The number of the lesions detected by T1-weighted imaging, T2-weighted imaging, diffusion-weighted imaging, dynamic contrast-enhanced, and delayed hepatobiliary-phase imaging was counted, respectively. Contrast-to-noise ratios were measured for all the sequences including delayed hepatobiliary-phase imaging. The signal intensity and morphologic features of liver parenchyma and lesions were recorded and analyzed.

Results There were 7 patients with hepatocellular carcinomas, 6 with hemangiomas, 7 with metastases, and 5 with cholangiocarcinomas. The delayed hepatobiliary-phase imaging showed a homogeneous enhancement of liver parenchyma and distinctive enhancement features of focal liver lesions. The delayed hepatobiliary-phase imaging was better than diffusion-weighted imaging for the detection of focal liver lesions (P < 0.05).

Conclusion The addition of hepatobiliary-phase imaging to Gd-BOPTA–enhanced dynamic imaging increased the sensitivity and accuracy for the detection of focal hepatic lesions.

From the *Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Sichuan, China; and †Department of Radiology, University of Southern California Keck School of Medicine.

Received for publication July 22, 2011; accepted October 18, 2011.

Reprints: Yong Du, MD, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, 63# Wen Hua Lu, Nanchong, Sichuan 637000, China (e-mail:

The authors report no conflicts of interest.

© 2012 Lippincott Williams & Wilkins, Inc.