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Computed Tomographic Cholangiography in Living Liver Transplant Donors: Factors Determining the Degree of Contrast Enhancement

Fetzer, David T. MD; Furlan, Alessandro MD; Wang, Jin-Hong MD; Kantartzis, Stamatis MD; Sholosh, Biatta MD; Bae, Kyongtae T. MD, PhD

Journal of Computer Assisted Tomography: November/December 2011 - Volume 35 - Issue 6 - p 716–722
doi: 10.1097/RCT.0b013e318237284c
Original Article

Objective To determine factors affecting liver and bile duct contrast enhancement during computed tomographic cholangiography (CTC) in living-donor transplant candidates.

Methods Forty-four candidates underwent preoperative triphasic CT followed by intravenous infusion of 20 mL of iodipamide for CTC. Body size indices and liver volume were correlated to parenchymal and biliary enhancement. Bile duct visibility was compared to duct enhancement.

Results Poorly visualized first- and second-order bile ducts demonstrated diminished enhancement (P < 0.015). Both CTC parenchymal and biliary enhancement correlated inversely with body surface area, height, and weight (P < 0.001); inverse correlation was also seen between liver volume and parenchymal enhancement (P < 0.001). A moderately positive correlation was noted between CTC biliary and parenchymal portal venous enhancement (r = 0.421; P = 0.004).

Conclusions Computed tomographic cholangiography parenchymal and biliary enhancement diminishes with increased body size and liver volume, supporting a need for adjustable contrast dosing. Portal venous parenchymal enhancement may serve as a preinfusion indicator.

From the Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Received for publication May 25, 2011; accepted September 12, 2011.

Reprints: Kyongtae T. Bae, MD, PhD, Department of Radiology, University of Pittsburgh School of Medicine, 3950 Presby South Tower, 200th Lothrop St, Pittsburgh, PA 15213 (e-mail:

The authors did not receive funding for this work.

The authors report no conflicts of interest.

© 2011 Lippincott Williams & Wilkins, Inc.