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Subcortical Low-Intensity and Restricted Diffusion After First Seizure in a Child

Cerase, Alfonso MD*; Leonini, Sara MD; Franceschini, Rossella MD; Grosso, Salvatore MD, PhD§; Venturi, Carlo MD*

Journal of Computer Assisted Tomography: July-August 2011 - Volume 35 - Issue 4 - p 501-503
doi: 10.1097/RCT.0b013e31821f5d14

Our purpose was to increase the knowledge about subcortical low-intensity images on long repetition time by describing brain magnetic resonance images of a young boy after his first spontaneous seizure. Evident in the epileptogenic area were transient images of reversible subcortical low intensity on long-repetition time, T2*-weighted, and b = 0 s/mm2 diffusion, isointense signal on b = 1000 s/mm2 diffusion, and restricted diffusion. Most likely, mechanism was axonal flow disruption with iron accumulation and free radicals production induced during seizure.

From the *Unit NINT Neuroimaging and Neurointervention, Azienda Ospedaliera Universitaria Senese, Policlinico "Santa Maria alle Scotte", Siena, Italy; †Section of Radiology, Department of Human Pathology, ‡Section of Ophthalmology, Department of Ophthalmology and Neurosurgery, and §Section of Pediatric Neurology, Department of Pediatrics, University of Siena, Siena, Italy.

Received for publication March 16, 2010; accepted March 17, 2010.

Reprints: Alfonso Cerase, MD, UOC NINT Neuroimmagini e Neurointerventistica, Dipartimento di Neuroscienze, Azienda Ospedaliera Universitaria Senese, Policlinico "Santa Maria alle Scotte", Viale Maria Bracci, 16-53100 Siena, Italia (e-mail:

No funding was received for this work from any organization.

© 2011 Lippincott Williams & Wilkins, Inc.