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Gd-EOB-DTPA as a Functional MR Cholangiography Contrast Agent: Imaging Gallbladder Filling in Patients With and Without Hepatobiliary Dysfunction

Smith, Andrew Dennis MD, PhD*; Veniero, Joseph C. MD, PhD

Journal of Computer Assisted Tomography: July-August 2011 - Volume 35 - Issue 4 - p 439-445
doi: 10.1097/RCT.0b013e31821f4e29
Abdominal Imaging

Objective: To evaluate cystic duct patency on hepatobiliary-phase magnetic resonance (MR) images after intravenous gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) administration.

Methods: A radiology information system search identified patients with gallbladders that had MR imaging after intravenous Gd-EOB-DTPA injection. No patients had acute cholecystitis. Magnetic resonance image findings were correlated with clinical notes, other imaging studies, time of contrast injection, and serum laboratory tests.

Results: Contrast accumulated in the gallbladder in 80% of patients (n = 100) with hepatobiliary-phase MR imaging at a median of 22 minutes (range, 15-83 minutes). Absence of contrast accumulation in the gallbladder (n = 20) was associated with hepatobiliary imaging less than 30 minutes after contrast administration, gallbladder contraction, cholelithiasis, elevated liver function tests, elevated bilirubin, and cirrhosis.

Conclusions: Functional assessment of cystic duct patency by Gd-EOB-DTPA-enhanced liver MR is best conducted when hepatobiliary-phase T1-weighted imaging is delayed by more than 30 minutes after contrast injection. Hepatobiliary dysfunction is associated with nonfilling of the gallbladder.

From the *Body Imaging Section, University of Mississippi Medical Center, Jackson, MS; and †Abdominal Imaging Section, Imaging Institute, Cleveland Clinic, Cleveland, OH.

Received for publication February 7, 2011; accepted April 12, 2011.

Reprints: Andrew D. Smith, MD, PhD, Department of Radiology, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216 (e-mail:

The authors did not receive any financial support for this work.

© 2011 Lippincott Williams & Wilkins, Inc.