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Magnetic Resonance Manifestations of Hyperreactio Luteinalis

Takeuchi, Mayumi MD, PhD; Matsuzaki, Kenji MD, PhD

Journal of Computer Assisted Tomography: May-June 2011 - Volume 35 - Issue 3 - p 343-346
doi: 10.1097/RCT.0b013e318218c09e
Abdominal Imaging

Objective: Hyperreactio luteinalis (HL) is a rare benign physiological ovarian enlargement associated with gestational trophoblastic disease or pregnancy, and may mimic neoplasm. We evaluated magnetic resonance findings of HL to distinguish from neoplasm by using diffusion-weighted imaging with apparent diffusion coefficient (ADC) measurement.

Methods: Magnetic resonance manifestations of 15 cases of HL in 8 women (mean age, 32 years) were retrospectively evaluated. Diffusion-weighted imaging (b = 0 and 800 seconds/mm2) was obtained in 11 cases of HL, and ADC was compared with that in solid portions of 18 ovarian cancers.

Results: All cases of HL appeared as multilocular cystic masses with septations mimicking mucinous cystic tumors. Intervening ovarian stroma exhibited hyperintensity on diffusion-weighted imaging. The ADC in ovarian stroma in HL was significantly higher than that in solid portions of ovarian cancers.

Conclusion: Ovarian stroma in HL may mimic solid tumorous components in mucinous tumors; however, high ADC reflecting edematous, luteinized stroma may be helpful for the diagnosis of HL.

From the Department of Radiology, University of Tokushima, Tokushima, Japan.

Received for publication November 28, 2010; accepted March 4, 2011.

Reprints: Mayumi Takeuchi, MD, PhD, Department of Radiology, University of Tokushima, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, Japan (e-mail:

Both authors have no conflicts of interest and have received no funding for research.

© 2011 Lippincott Williams & Wilkins, Inc.