Review ArticleIs Brain SPECT Useful in Degenerative Dementia Diagnosis?Farid, Karim MD*; Caillat-Vigneron, Nadine MD, PhD*†; Sibon, Igor MD, PhD‡Author Information From the *Department of Nuclear Medicine, Hôtel Dieu Hospital, Paris, France; †University of Paris Descartes, Paris, France; and ‡Department of Neurology, Pellegrin Hospital, Bordeaux, France. Received for publication June 16, 2010; accepted July 11, 2010. Reprints: Karim Farid, MD, Department of Nuclear Medicine, Hôtel Dieu Hospital, 1, Place du Parvis Notre Dame, 75181 Paris, France (e-mail: email@example.com). The authors do not have conflicts of interest. The authors did not receive financial support for this work. Journal of Computer Assisted Tomography: January-February 2011 - Volume 35 - Issue 1 - p 1-3 doi: 10.1097/RCT.0b013e3181f56fda Buy Metrics Abstract Cerebral blood flow assessment performed by single-photon emission computed tomography (SPECT) of the brain is used to detect early neuronal dysfunction associated with degenerative dementia. Patterns of perfusion abnormalities are different across dementia syndromes. These differences could be used for differential diagnoses and early detection of amnesic mild cognitive impairment in patients with a high risk of conversion to Alzheimer disease. This paper aimed to summarize the expected benefits of single-photon emission computed tomography of the brain in the exploration of degenerative dementias. © 2011 Lippincott Williams & Wilkins, Inc.