Phase-contrast magnetic resonance imaging can potentially assess the dynamics of left ventricular (LV) early diastolic filling.
Fifteen participants underwent phase-contrast magnetic resonance imaging on a 1.5-T whole-body Avanto scanner (Siemens Healthcare, Erlangen, Germany). Left ventricular intracavitary velocities were measured in 3 orthogonal directions. Imaging parameters included a repetition time of 92.45 milliseconds, an echo time of 2.88 milliseconds, a flip angle of 30 degrees, and a velocity-encoding range of 100 to 150 cm/s.
The color vector analysis provided a visual assessment of LV diastolic flow. In normal subjects, there was rapid organized early diastolic flow that extended from the mitral valve to the LV apex. In patients with LV diastolic dysfunction, organized high-velocity flow stopped in the mid-left ventricle.
Four-dimensional phase-contrast cardiovascular magnetic resonance can differentiate between normal and abnormal diastolic flow propagation within the left ventricle.
From the *Section of Cardiology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC; †Department of Mechanical Engineering, School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, Virginia; ‡Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC; and §Siemens Healthcare, Cardiovascular Magnetic Resonance Research and Development, Chicago, IL.
Received for publication July 14, 2010; accepted October 4, 2010.
Reprints: William C. Little, MD, Cardiology Section, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157-1045 (e-mail: firstname.lastname@example.org).
Dr Hundley receives research support from the National Institutes of Health, Susan Komen Foundation, Astellas Pharmaceuticals, Siemens Healthcare, and Bracco Diagnostics for cardiovascular imaging research. Drs Hundley and Hamilton own a minority share of Prova, Inc, a company that performs cardiovascular image management and display. Mr McNeal is an employee of Siemens Healthcare who supplied the software.