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Magnetic Resonance Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion Imaging in the Diagnosis of Posterior Fossa Hemangioblastomas and Pilocytic Astrocytomas: Initial Results

Kumar, Vinodh A. MD*; Knopp, Edmond A. MD; Zagzag, David MD, PhD

Journal of Computer Assisted Tomography: November-December 2010 - Volume 34 - Issue 6 - p 825-829
doi: 10.1097/RCT.0b013e3181ef77e2

Objective: The purpose of this study was to compare the dynamic susceptibility-weighted contrast-enhanced (DSC) magnetic resonance (MR) perfusion and MR imaging findings between hemangioblastomas and pilocytic astrocytoma (PA).

Methods: We retrospectively identified 6 patients with hemangioblastomas and 8 patients with PAs who underwent MR imaging before resection. Using fluid-attenuated inversion-recovery imaging, we graded peritumoral edema as absent, minimal, mild, moderate, or severe. In addition, 3 patients with hemangioblastomas and 4 patients with PAs underwent DSC-MR imaging before resection.

Results: We observed moderate to severe peritumoral edema in 6 patients with hemangioblastomas and none or minimal peritumoral edema in 8 patients with PAs. The mean relative cerebral blood volume was 7.7 (SD, 1.0) in patients with hemangioblastomas and 1.8 (SD, 1.8) in patients with PAs.

Conclusions: Our preliminary findings demonstrate significantly higher DSC-MR imaging relative cerebral blood volumes in patients with hemangioblastomas when compared with patients with PAs. In addition, moderate to severe peritumoral edema was associated with hemangioblastomas.

From the *Department of Diagnostic Radiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX; Departments of †Radiology and ‡Pathology, New York University Langone Medical Center, New York, NY.

Received for publication December 29, 2010; accepted March 12, 2010.

Reprints: Vinodh A. Kumar, MD, Department of Diagnostic Radiology, Unit 370, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 (e-mail:

Presented at the annual meeting of the American Society on Neuroradiology, June 9-14, 2007, Chicago, IL.

© 2010 Lippincott Williams & Wilkins, Inc.