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Myocardial Perfusion Magnetic Resonance Imaging Using Sliding-Window Conjugate-Gradient HYPR Methods in Canine With Stenotic Coronary Arteries

Ge, Lan MS*†; Kino, Aya MD*; Lee, Daniel MD*; Dharmakumar, Rohan PhD*†; Carr, James C. MD*; Li, Debiao PhD*†

Journal of Computer Assisted Tomography: September-October 2010 - Volume 34 - Issue 5 - p 684-688
doi: 10.1097/RCT.0b013e3181e9e9dd
Cardiovascular Imaging

Purpose: First-pass perfusion magnetic resonance imaging (MRI) is a promising technique for detecting ischemic heart disease. However, the diagnostic value of the method is limited by the low spatial coverage, resolution, signal-to-noise ratio (SNR), and cardiac motion-related image artifacts. A combination of sliding window and conjugate-gradient HighlY constrained back-PRojection reconstruction (SW-CG-HYPR) method has been proposed in healthy volunteer studies to reduce the acquisition window for each slice while maintaining the temporal resolution of 1 frame per heartbeat in myocardial perfusion MRI. This method allows for improved spatial coverage, resolution, and SNR.

Methods: In this study, we use a controlled animal model to test whether the myocardial territory supplied by a stenotic coronary artery can be detected accurately by SW-CG-HYPR perfusion method under pharmacological stress.

Results: Results from 6 mongrel dogs (15-25 kg) studies demonstrate the feasibility of SW-CG-HYPR to detect regional perfusion defects. Using this method, the acquisition time per cardiac cycle was reduced by a factor of 4, and the spatial coverage was increased from 2 to 3 slices to 6 slices as compared with the conventional techniques including both turbo-Fast Low Angle Short (FLASH) and echoplanar imaging (EPI). The SNR of the healthy myocardium at peak enhancement with SW-CG-HYPR (12.68 ± 2.46) is significantly higher (P < 0.01) than the turbo-FLASH (8.65 ± 1.93) and EPI (5.48 ± 1.24). The spatial resolution of SW-CG-HYPR images is 1.2 × 1.2 × 8.0 mm3, which is better than the turbo-FLASH (1.8 × 1.8 × 8.0 mm3) and EPI (2.0 × 1.8 × 8.0 mm3).

Conclusions: Sliding-window CG-HYPR is a promising technique for myocardial perfusion MRI. This technique provides higher image quality with respect to significantly improved SNR and spatial resolution of the myocardial perfusion images, which might improve myocardial perfusion imaging in a clinical setting.

From the Departments of *Radiology and, †Biomedical Engineering, Northwestern University, Chicago, IL.

Received for publication February 10, 2010; accepted May 17, 2010.

Reprints: Debiao Li, PhD, Suite 1600, 737 N Michigan Ave, Chicago, IL 60611 (e-mail:

Grant support was received from an American Heart Association fellowship grant, NIBIB EB002623, NHLBI HL38698 and Siemens Medical Solutions USA, Inc., Malvern, PA.

© 2010 Lippincott Williams & Wilkins, Inc.