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Breath-Hold 1H-Magnetic Resonance Spectroscopy for Intrahepatic Lipid Quantification at 3 Tesla

Bredella, Miriam A. MD*; Ghomi, Reza Hosseini MSE*; Thomas, Bijoy J. MD*; Ouellette, Hugue A. MD*; Sahani, Dushyant V. MD*; Miller, Karen K. MD; Torriani, Martin MD*

Journal of Computer Assisted Tomography: May-June 2010 - Volume 34 - Issue 3 - p 372-376
doi: 10.1097/RCT.0b013e3181cefb89
Abdominal Imaging

Objective: To compare breath-hold 1H-magnetic resonance spectroscopy (1H-MRS) with respiratory-gated 1H-MRS and computed tomography (CT) for quantification of hepatic lipid content.

Methods: Twenty-three premenopausal women underwent breath-hold point-resolved single-voxel 1H-MRS of the liver followed by respiratory-gated 1H-MRS at 3 Tesla and CT slice through the liver. Interscan variability for 1H-MRS was assessed in 6 volunteers. Pearson correlation coefficients, Bland-Altman 95% limit of agreement, and concordance correlation coefficients were calculated.

Results: There was a strong correlation between breath-hold and respiratory-gated 1H-MRS (r = 0.94, P < 0.0001; concordance correlation coefficient, 0.75). Using Bland-Altman analysis, all but 2 data points were within the limits of agreement. Both 1H-MRS techniques had low interscan variability. There was an inverse correlation of both 1H-MRS techniques with CT attenuation values of the liver.

Conclusions: Breath-hold 1H-MRS is a reliable method to measure hepatic lipid content at 3 Tesla. Breath-hold 1H-MRS of the liver provides data that closely correlates with that obtained from longer-duration respiratory-gated technique.

From the *Department of Radiology, and †Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA.

Received for publication August 28, 2009; accepted December 9, 2009.

Reprints: Miriam A. Bredella, MD, Massachusetts General Hospital, Yawkey 6E, 55 Fruit St, Boston, MA 02114 (e-mail:

This work was supported in part by National Institutes of Health Grants RO1 HL-077674, UL1 RR025758, and K23 RR-23090.

Disclosures: The authors have nothing to disclose.

© 2010 Lippincott Williams & Wilkins, Inc.