Abdominal ImagingOptimized Multidetector Computed Tomographic Protocol for the Diagnosis of Active Obscure Gastrointestinal Bleeding A Feasibility StudyHeiss, Peter MD*; Zorger, Niels MD*; Hamer, Okka W. MD*; Seitz, Johannes MD*; Müller-Wille, Rene MD*; Koller, Michael MD‡; Herold, Thomas MD*; Schölmerich, Jürgen MD†; Feuerbach, Stefan MD*; Wrede, Christian E. MD†Author Information From the Departments of *Radiology, †Internal Medicine I, and ‡Center for Clinical Trials, University of Regensburg, Regensburg, Germany. Received for publication October 4, 2008; accepted October 23, 2008. Reprints: Peter Heiss, MD, Department of Radiology, University of Regensburg, 93042 Regensburg, Germany (e-mail: [email protected]). No funding was received for this work. Journal of Computer Assisted Tomography: September 2009 - Volume 33 - Issue 5 - p 698-704 doi: 10.1097/RCT.0b013e3181937f1b Buy Metrics Abstract Objective: The purpose of this feasibility study was to prospectively evaluate an optimized multidetector computed tomographic protocol for the diagnosis of active obscure gastrointestinal bleeding (OGIB). Methods: Between October 2006 and February 2008, patients admitted for active OGIB were included in this prospective unicenter study. Water was administered orally and rectally as neutral luminal contrast material. A contrast-enhanced 16-row multidetector computed tomography (MDCT) was performed in the arterial and venous phases. Mesenteric digital subtraction angiography was carried out immediately after MDCT as standard of reference. Results: Six patients were included in this study. Multidetector computed tomography identified the bleeding site and source in 5 (83%) of the patients. Digital subtraction angiography was performed in 4 patients, and the result was positive in 1 (25%) of the patients. Multidetector computed tomography detected the site and source of bleeding in 2 patients whose digital subtraction angiographic result was negative. Conclusions: The results of this feasibility study indicate that optimized MDCT is an excellent diagnostic tool for the diagnosis of active OGIB. © 2009 Lippincott Williams & Wilkins, Inc.