Breast Imaging: Original ArticleEvaluation of Suspicious Nipple Discharge by Magnetic Resonance Mammography Based on Breast Imaging Reporting and Data System Magnetic Resonance Imaging DescriptorsTokuda, Yukiko MD*; Kuriyama, Keiko MD*; Nakamoto, Atsushi MD†; Choi, Soomi MD*; Yutani, Kenji MD*; Kunitomi, Yuki MD*; Haneda, Takashi MD*; Kawai, Misa MD*; Masuda, Norikazu MD‡; Takeda, Masashi MD§; Nakamura, Hironobu MD†Author Information From the *Department of Radiology, National Hospital Organization Osaka National Hospital; †Department of Radiology, Osaka University Graduate School of Medicine, Faculty of Medicine; and Departments of ‡Surgery, and §Pathology, National Hospital Organization Osaka National Hospital, Osaka, Japan. Received for publication October 13, 2007; accepted January 3, 2008. Reprints: Yukiko Tokuda, MD, Department of Radiology, National Hospital Organization, Osaka National Hospital, Osaka Prefecture, 2-1-14 Hoenzaka, Chuo-ku, Osaka 540-0006, Japan (e-mail: [email protected]). Journal of Computer Assisted Tomography: January 2009 - Volume 33 - Issue 1 - p 58-62 doi: 10.1097/RCT.0b013e3181671ad2 Buy Metrics Abstract Purpose: To evaluate the findings of magnetic resonance mammography for suspicious nipple discharge based on breast imaging-reporting and data system magnetic resonance imaging (MRI) descriptors and establish any correlations with the histopathologic diagnoses. Methods: Forty-seven patients with suspicious nipple discharge underwent MRI using a 1.5-T system. Images were evaluated for a signal of abnormal discharge, related abnormal enhancement according to the breast imaging-reporting and data system MRI descriptors, and the presence of clustered ring enhancement and were compared with the histopathologic diagnoses established in 39 lesions. Results: The most common finding in patients with suspicious nipple discharge was non-masslike enhancement. Seventeen malignant and 22 benign lesions were detected. The most frequent findings in the malignant lesions were "segmental" (59%), "heterogeneous" (57%), and plateau pattern (40%). Clustered ring enhancement was found in 60% of the enhanced malignant lesions (P = 0.002). The combination of segmental distribution and clustered ring enhancement showed a significant association with malignant lesions (P = 0.004). Conclusions: Magnetic resonance imaging provides clinically useful information in patients with suspicious nipple discharge. © 2009 Lippincott Williams & Wilkins, Inc.