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Association, Commissural, and Projection Pathways and Their Functional Deficit Reported in Literature

Aralasmak, Ayse MD*†; Ulmer, John L. MD; Kocak, Mehmet MD†‡; Salvan, Carmen V. MD; Hillis, Argye E. MD§; Yousem, David M. MD, MBA*

Journal of Computer Assisted Tomography: September-October 2006 - Volume 30 - Issue 5 - p 695-715
doi: 10.1097/01.rct.0000226397.43235.8b
Nueroradiology: Review Article

Abstract: This study demonstrates normal white matter structures of the supratentorial system revealed by diffusion tensor imaging. Their anatomic connections and functional significance are discussed in the context of the lesion-induced deficits reported in the literature, which may not fully represent the lesion-induced effects on the white matter function and may not be entirely specific to the tract discussed. Nevertheless, understanding the most common effects of lesions on the functional connectivity provides a framework that we can use in advanced neuroimaging studies, like diffusion tensor imaging, functional magnetic resonance imaging, and positron emission tomography, and in our daily clinical practice.

From the *Russell H. Morgan Department of Radiology and Radiological Science, Division of Neuroradiology, Johns Hopkins Medical Institution, Baltimore, MD; †Division of Neuroradiology and Department of Radiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI; ‡Department of Radiology, Clement J. Zablocki VA Medical Center, 5000 W. National Avenue, Milwaukee, WI; and §Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD.

Reprints: Ayse Aralasmak, MD, 600 N Wolfe St/Phipps B-112, Baltimore, MD 21287 (e-mail:

© 2006 Lippincott Williams & Wilkins, Inc.