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High-Concentration Contrast Media in Multiphasic Abdominal Multidetector-Row Computed Tomography: Effect of Increased Iodine Flow Rate on Parenchymal and Vascular Enhancement

Schoellnast, Helmut MD*; Brader, Peter MD*; Oberdabernig, Barbara MD*; Pisail, Borjana MD*; Deutschmann, Hannes A MD*; Fritz, Gerald A MD*; Schaffler, Gottfried MD*; Tillich, Manfred MD

Journal of Computer Assisted Tomography: September-October 2005 - Volume 29 - Issue 5 - p 582-587
doi: 10.1097/01.rct.0000175502.79954.96
Abdominal Imaging: Original Article
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Objective: The purpose of this study was to assess the influence of the iodine flow rate on parenchymal and vascular enhancement during multiphasic abdominal multidetector-row computed tomography (MDCT).

Methods: Fifteen patients underwent MDCT at an iodine flow rate of 1.2 g/s as well as 1.6 g/s (group A, protocols 1 and 2), and 90 patients underwent MDCT at an iodine flow rate of 1.2 g/s (group B) or 1.6 g/s (group C). Measurements were performed for all groups in the liver, spleen, pancreas, portal vein, inferior vena cava, and abdominal aorta.

Results: Aortal and pancreatic enhancement during the arterial phase was significantly higher with the higher iodine flow rate. The mean difference in aortal enhancement was 60 Hounsfield units (HU) between protocols 1 and 2 of group A, and the mean difference was 70 HU between groups B and C. The mean difference in pancreatic enhancement was 10 HU between protocols 1 and 2 of group A and 17 HU between groups B and C. During the portal and hepatic venous phases, no significant difference in enhancement was observed.

Conclusion: A high iodine flow rate in multiphasic abdominal MDCT improves enhancement of the aorta and the pancreas during the arterial phase but does not influence later phases.

From the *Department of Radiology, Medical University and University Hospital Graz, Graz, Austria, and †Diagnostikum Graz Sued-West, Graz, Austria.

Received for publication April 23, 2005; accepted June 16, 2005.

Reprints: Helmut Schoellnast, Department of Radiology, Medical University and University Hospital Graz, Auenbruggerplatz 9, A-8036 Graz, Austria (e-mail: helmut.schoellnast@meduni-graz.at).

© 2005 Lippincott Williams & Wilkins, Inc.