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3-T Proton Magnetic Resonance Spectroscopy of Central Neurocytoma: 3 Case Reports and Review of the Literature

Chuang, Ming-Tsung MD*; Lin, Wei-Chen MD*; Tsai, Huei-Yi MD*; Liu, Gin-Chung MD*; Hu, Shih-Wen MD; Chiang, I-Chan MD*

Journal of Computer Assisted Tomography: September-October 2005 - Volume 29 - Issue 5 - p 683-688
doi: 10.1097/01.rct.0000171240.95430.29
Neuroimaging: Case Report
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Central neurocytoma (CNC), first described by Hassoun et al in 1982, is a rare neuronal tumor of the central nervous system, accounting for 0.25% to 0.5% of all central nervous system tumors. To our knowledge, there are only 5 published articles reporting the magnetic resonance spectroscopy (MRS) findings of neurocytomas. The 3-T proton MRS findings of 3 cases with CNC confirmed by immunohistochemical stains are reported here. Increased choline (Cho)/creatine (Cr) ratios with decreased N-acetylaspartate (NAA)/Cr ratios were observed in all 3 cases, but only 1 case had an increased peak at 3.55 ppm known as glycine (Gly). The other case with an increased alanine peak at 1.5 ppm had a poor prognosis. Therefore, we conclude that the presence of a Gly peak may suggest the diagnosis of CNC but that the absence of Gly does not exclude the diagnosis of CNC.

From the *Department of Medical Imaging, Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China, and †Department of Pathology, Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China.

Received for publication April 18, 2005; accepted May 11, 2005.

Reprints: I-Chan Chiang, Department of Medical Imaging, Chung-Ho Memorial Hospital, Kaohsiung Medical University, No. 100 Tz-You 1st Road, Kaohsiung, 807, Taiwan, Republic of China (e-mail: u8501122@gmail.com).

© 2005 Lippincott Williams & Wilkins, Inc.