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Neurofibromatosis Type 1: Spinal Manifestations of a Systemic Disease

Restrepo, Carlos S MD; Riascos, Roy F MD; Hatta, Ami A MD; Rojas, Rafael MD

Journal of Computer Assisted Tomography: July-August 2005 - Volume 29 - Issue 4 - p 532-539
doi: 10.1097/01.rct.0000163705.21892.23
Neuroimaging: Pictorial Essay
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Neurofibromatosis type 1 (NF1) is an autosomal dominant congenital dysplasia of the neural crest cells that affects the development of tissue and structures arising from the 3 germinal layers. Affected patients may present with spinal deformities or with bone or soft tissue abnormalities. Imaging plays an important role in the evaluation of these patients. In this article, a working diagnosis approach is proposed and the spectrum of spinal imaging findings in the NF1 patient is reviewed.

From the Department of Radiology, Louisiana State University Health Sciences Center, New Orleans, LA.

Received for publication March 2, 2005; accepted March 14, 2005.

Reprints: Roy F. Riascos, Department of Radiology, Louisiana State University, Health Sciences Center, 1542 Tulane Avenue, Room 212, New Orleans, LA 70112 (e-mail: riascosr@hotmail.com).

© 2005 Lippincott Williams & Wilkins, Inc.