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Flat-Panel Volumetric Computed Tomography: A New Method for Visualizing Fine Bone Detail in Living Mice

Obert, Martin*; Ahlemeyer, Barbara; Baumgart-Vogt, Eveline; Traupe, Horst*

Journal of Computer Assisted Tomography: July-August 2005 - Volume 29 - Issue 4 - p 560-565
doi: 10.1097/01.rct.0000164254.66730.55
Whole Body Imaging: Technical Note
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In this report, we present a new noninvasive 3-dimensional (3D) imaging technology for in vivo monitoring of the skeletal development of mice: flat-panel volumetric Computed Tomography (fpvCT). Long-term investigations of 4 mice are presented, with up to 14 scans of each mouse from postnatal day 0 to 86. Examinations of a newborn and an adult mouse, performed with fpvCT and clinical multislice CT (MSCT), demonstrate the superior image quality of high-resolution fpvCT.

From the *Universitätsklinikum Giessen, Abteilung Neuroradiologie, Giessen, Germany; and the †Institut für Anatomie und Zellbiologie, AG Medizinische Zellbiologie, Justus-Liebig-Universität Giessen, Giessen, Germany.

Received for publication October 27, 2004; accepted March 21, 2005.

Reprints: Martin Obert, Abteilung Neuroradiologie, Universitätsklinikum Giessen, Klinikstrasse 29, D-35385 Giessen, Germany (e-mail: martin.obert@radiol.med.uni-giessen.de).

© 2005 Lippincott Williams & Wilkins, Inc.