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Bronchiolitis Obliterans Organizing Pneumonia After Bone Marrow Transplantation: High-Resolution Computed Tomography Findings in 4 Patients

Dodd, Jonathan D MD, MSc; Müller, Nestor L MD, PhD

Journal of Computer Assisted Tomography: July-August 2005 - Volume 29 - Issue 4 - p 540-543
doi: 10.1097/01.rct.0000164035.77703.06
Thoracic Imaging: Original Article

Objective: To assess the high-resolution computed tomography (HRCT) appearances of bronchiolitis obliterans organizing pneumonia (BOOP) after bone marrow transplantation (BMT).

Methods: The HRCT scans obtained in 4 patients (2 men and 2 women, age range: 20-50 years, mean age = 36 years) with biopsy-proven BOOP after BMT were reviewed retrospectively by 2 observers for the presence, extent, and distribution of parenchymal abnormalities.

Results: All patients demonstrated consolidation and ground-glass opacity. The consolidation was bilateral, patchy, and asymmetric in all patients and was predominantly peribronchovascular in 3 patients and subpleural and peribronchovascular in 1 patient. Ground-glass opacity was patchy and asymmetric in all patients and was bilateral in 3 patients and unilateral in 1 patient. No zonal predominance of either feature could be identified.

Conclusions: The predominant HRCT features of BOOP after BMT are bilateral, patchy, and asymmetric consolidation in a predominantly peribronchovascular distribution with associated ground-glass opacity.

From the Department of Radiology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.

Received for publication January 5, 2005; accepted March 16, 2005.

Reprints: Nestor L. Müller, Department of Radiology, Vancouver General Hospital, 899 West 12th Avenue, Vancouver, British Columbia, Canada V5Z 1M9 (e-mail:

© 2005 Lippincott Williams & Wilkins, Inc.