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Optimizing Scan Delays of Fixed Duration Contrast Injection in Contrast-Enhanced Biphasic Multidetector-Row CT for the Liver and the Detection of Hypervascular Hepatocellular Carcinoma

Kanematsu, Masayuki MD*†; Goshima, Satoshi MD*; Kondo, Hiroshi MD*; Nishibori, Hironori MD*; Kato, Hiroki MD*; Yokoyama, Ryujiro MS, RT; Miyoshi, Toshiharu RT; Hoshi, Hiroaki MD*; Onozuka, Minoru PhD; Moriyama, Noriyuki MD§

Journal of Computer Assisted Tomography: March-April 2005 - Volume 29 - Issue 2 - p 195-201
doi: 10.1097/01.rct.0000155062.50236.59
Original Article: Abdominal Imaging

Objective: To determine the optimal scan delay required for fixed duration contrast injection in contrast-enhanced biphasic multidetector-row CT for the liver and the detection of hypervascular hepatocellular carcinoma (HCC).

Methods: CT images (2.5-mm collimation, 5-mm thickness with no intersectional gap) were obtained after an intravenous bolus injection of 2 mL/kg of nonionic iodine contrast material (300 mg I/mL) for a fixed 30-second injection in 206 patients, who were prospectively randomized into four groups, for which scans were initiated at −5, 15, and 35 seconds; at 0, 20, and 40 seconds; at 5, 25, and 45 seconds; or at 10, 30, and 50 seconds for the first (acquisition time: 4.3 seconds), second (4.3 seconds), and third (9.1 seconds) phases, respectively, after the completion of contrast injection. Mean CT values (HU) of the abdominal aorta, spleen, main portal veins, liver parenchyma, and hepatic veins were measured. Increases in CT values between pre- and post-contrast CTs (ΔHU) for the organs, and spleen-to-liver and HCC-to-liver contrast differences (δHU) were assessed.

Results: Abdominal aorta reached 273-301 ΔHU at −5 to 10 seconds with a peak (301 ΔHU) at 5 seconds. Spleen peaked (115 ΔHU) at 10 seconds. Liver parenchyma were enhanced weakly (11-34 ΔHU) at −5 to 10 seconds, exceeded 50 ΔHU at 20 seconds, peaked (61 ΔHU) at 30 seconds, and then plateaued (54-58 ΔHU) at 35-50 seconds. Hepatic veins were enhanced weakly (14-37 ΔHU) at −5 to 10 seconds, and reached 67 ΔHU at 15 seconds. Spleen-to-liver (65-69 δHU) and HCC-to-liver (31-34 δHU) contrast differences were highest at 5-10 seconds. Qualitative results corresponded well with quantitative results.

Conclusions: For the detection of hypervascular HCCs, the optimal scan delay after a 30-second contrast injection of the hepatic arterial phase, was found to range from 5 to 10 seconds, and that of the portal venous phase was 35 seconds or somewhat longer.

From the *Department of Radiology, Gifu University School of Medicine, Gifu, Japan; †Department of Radiology Services, Gifu University Hospital, Gifu, Japan; ‡Department of Physiology and Neuroscience, Kanagawa Dental College, Yokosuka, Japan; and §Department of Diagnostic Radiology, National Cancer Center Hospital, Tsukiji, Japan.

Received for publication October 24, 2004; accepted December 20, 2004.

Supported in part by the Grant for Scientific Research Expenses for Health Labour and Welfare Programs; by the Foundation for the Promotion of Cancer Research; and by the Research on Cancer Prevention and Health Services.

Reprints: Masayuki Kanematsu, Department of Radiology Services, Gifu University Hospital, 1-1 Yanagido, Gifu 501-1193, Japan (e-mail:

© 2005 Lippincott Williams & Wilkins, Inc.