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Propylene Glycol Is Essential in the LCModel Basis Set for Pediatric 1H-MRS

Oakden, Wendy K BMath*†‡; Noseworthy, Michael D PhD*†§∥

Journal of Computer Assisted Tomography: January-February 2005 - Volume 29 - Issue 1 - p 136-139
doi: 10.1097/01.rct.0000145860.13963.2f
Technical Note: Neuroradiology

Propylene glycol (PG) is an organic solvent used in a variety of parenterally injected pharmaceutical preparations. In this current study, we analyzed neonatal brains following routine MRS evaluation at 1.5 T, using the LCModel software, with and without the addition of PG to the analysis basis-set. We suggest including PG in the LCModel basis-set for neonatal brain 1H-MRS to improve the discrimination and quantification of lactate and inositol.

From the *The Imaging Research Centre, Brain Body Institute, St. Joseph's Healthcare, Hamilton, Ontario, Canada; †Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada; ‡Department of Medical Biophysics, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada; §Departments of Radiology and Medical Physics & Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada; and ∥Department of Medical Imaging, The University of Toronto, Toronto, Ontario, Canada.

Received for publication August 19, 2004; accepted September 13, 2004.

Supported by the Behavioral Research and Imaging Network (B.R.A.I.N.), Ontario Research and Development Challenge Fund (ORDCF).

Originally presented as an e-poster at the International Society for Magnetic Resonance in Medicine (ISMRM) annual meeting in Kyoto Japan, May 2004.

Reprints: Michael D. Noseworthy, Imaging Research Centre, St. Joseph's Healthcare, 50 Charlton Avenue, E. Hamilton, Ontario L8N 4A6, Canada (e-mail:

© 2005 Lippincott Williams & Wilkins, Inc.