Supplement ArticleComputed Tomography Contrast Enhancement Principles and the Use of High-Concentration Contrast MediaHerman, Sean MDAuthor Information From the Department of Diagnostic Radiology, Yale New Haven Hospital, New Haven, CT. Reprints: Sean Herman, MD, 29 Scofield Avenue, Stamford, CT, 06906 (e-mail: [email protected]). Journal of Computer Assisted Tomography: July/August 2004 - Volume 28 - Issue - p S7-S11 doi: 10.1097/01.rct.0000120855.80935.2f Buy Metrics Abstract Numerous pharmacokinetic and physiologic interactions are involved in the utilization of iodinated contrast in computed tomography. Patient related factors, injection related variables including contrast material concentration, and intravascular and organ specific imaging techniques are but a few of the principles that must be understood. With the advancement of faster CT scanners, these factors must be considered for optimal contrast enhancement. © 2004 Lippincott Williams & Wilkins, Inc.