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Diffusion-Weighted Half-Fourier Single-Shot Turbo Spin Echo Imaging in Breast Tumors: Differentiation of Invasive Ductal Carcinoma from Fibroadenoma

Kinoshita, Takahiro; Yashiro, Naobumi; Ihara, Nobumaro; Funatu, Hiroyuki; Fukuma, Eisuke; Narita, Makoto

Journal of Computer Assisted Tomography: November-December 2002 - Volume 26 - Issue 6 - p 1042-1046
Breast Imaging

Purpose The purpose of this investigation is to evaluate the usefulness of diffusion-weighted half-Fourier single-shot turbo spin echo (DW-HASTE) imaging in differentiating invasive ductal carcinoma from fibroadenoma.

Method The DW-HASTE imaging was performed in patients with invasive ductal carcinoma (n = 16) and fibroadenoma (n = 6). Images were obtained with diffusion-sensitizing gradients of 0 and 700 mm2/s. The apparent diffusion coefficient (ADC) was calculated.

Results The DW–HASTE imaging was not affected with susceptibility and chemical shift artifacts usually present in DW echo planar imaging. The DW-HASTE imaging had low tumor detectability (62%), however. The difference in mean ADC of invasive ductal carcinoma (1.216 ± 0.189 × 10−3mm2/s) and fibroadenoma (1.495 ± 0.181 × 10−3mm2/s) was statistically significant.

Conclusion Apparent diffusion coefficient measurement using DW-HASTE imaging is helpful in differentiating invasive ductal carcinoma from fibroadenoma. Nevertheless, DW-HASTE imaging has low detectability at present; therefore, more technologic improvement is desired.

From the Departments of Radiology (T. Kinoshita, N. Yashiro, N. Ihara, and H. Funatu), Surgery (E. Fukuma), and Pathology (M. Narita), Kameda Medical Center, Chiba, Japan.

Address correspondence and reprint requests to Dr. Takahiro Kinoshita, Department of Radiology, Chigasaki Tokushukai General Hospital, 14-1 Saiwai-cho, Chigasaki-City, Kanagawa 253–0052, Japan. E-mail:

© 2002 Lippincott Williams & Wilkins, Inc.