ABDOMINAL IMAGINGDetection of Hypervascular Hepatocellular Carcinoma: Comparison of SPIO-enhanced MRI With Dynamic Helical CTHori, Masatoshi; Murakami, Takamichi; Kim, Tonsok; Tsuda, Kyo; Takahashi, Satoru; Okada, Atsuya; Takamura, Manabu; Nakamura, HironobuAuthor Information From the Department of Radiology, Osaka University Graduate School of Medicine, Osaka, Japan. Address correspondence and reprint requests to Dr. M. Hori at Department of Radiology, Osaka University Graduate School of Medicine, D1, 2–2, Yamadaoka, Suita-city, Osaka 565-0871, Japan. E-mail: firstname.lastname@example.org Journal of Computer Assisted Tomography: September-October 2002 - Volume 26 - Issue 5 - p 701-710 Buy Abstract Purpose The purpose of this study was to compare the diagnostic performance of superparamagnetic iron oxide (SPIO)-enhanced MRI for the detection of hypervascular hepatocellular carcinoma (HCC) with dynamic helical CT. Methods SPIO-enhanced MR and dynamic helical CT images obtained from 41 patients with 52 hypervascular HCCs (5–130 mm; mean, 27 mm) were retrospectively analyzed. MRI were obtained with 1.5 T scanners using T2-weighted and proton density-weighted spin-echo (or fast spin-echo) sequences for all cases and a T2*-weighted gradient echo sequence for 36 cases. Four blinded observers reviewed images independently. Diagnostic accuracy was evaluated using alternative-free response receiver operating characteristic (AFROC) method. Sensitivities and positive predictive values (PPV) were also evaluated. Results The areas under the AFROC curves for each observer were greater for MR than for CT (means, 0.81 and 0.76; p < 0.05). The mean sensitivities for MR and CT were 0.75 and 0.71, respectively (p = 0.13). The mean PPVs were 0.83 and 0.79 (p = 0.21). Conclusion SPIO-enhanced MRI showed slightly better diagnostic performance than dynamic helical CT for the detection of hypervascular HCCs. © 2002 Lippincott Williams & Wilkins, Inc.