NEURORADIOLOGYShort-Echo Time Proton MR Spectroscopy in the Presence of GadoliniumLin, Alexander P.; Ross, Brian D.Author Information From the Magnetic Resonance Spectroscopy Unit, Huntington Medical Research Institutes, Pasadena, CA, U.S.A. Address correspondence and reprint requests to Dr. B. D. Ross at Huntington Medical Research Institutes, 660 S. Fair Oaks Ave., Pasadena, CA 91105, U.S.A. E-mail: firstname.lastname@example.org Journal of Computer Assisted Tomography: September-October 2001 - Volume 25 - Issue 5 - p 705-712 Buy Abstract Purpose The purpose of this work was to quantify the impact of contrast agents on short-TE single-voxel 1H MR spectroscopy (MRS) diagnosis of recurrent brain tumors. Method Short-TE 1H MRS was performed in 49 patients with biopsy-proven brain tumors and 14 control subjects. Eight patients (nine paired exams) were examined before and after administration of Gd-DTPA (interval approximately 5–7 min). Results Tumor spectra showed increased choline/creatine ratio (Cho/Cr; p < 0.009) and Cho concentrations (p < 0.02). Receiver operator characteristic for Cho/Cr = 0.93 differentiated 100% of tumors from control in the absence or presence of contrast agent. Repeated 1H MRS varied <3%. Cho T2 was significantly longer than Cr T2 (p < 0.02). Conclusion Proton MRS with TE of 30 ms may safely be used in combined contrast-enhanced MRI/MRS protocols. Further study is required with long-TE MRS because of the prolonged T2 of Cho. © 2001 Lippincott Williams & Wilkins, Inc.