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The Impact of Peak Saturation of the Arterial Input Function on Quantitative Evaluation of Dynamic Susceptibility Contrast-Enhanced MR Studies

Ellinger, Raimund; Kremser, Christian; Schocke, Michael F. H.; Kolbitsch, Christian; Griebel, Jürgen; Felber, Stephan R.; Aichner, Franz T.

Journal of Computer Assisted Tomography: November-December 2000 - Volume 24 - Issue 6 - p 942-948

Purpose The purpose of this work was to investigate systematic errors in dynamic contrast-enhanced MR perfusion studies due to peak saturation of the arterial input function (AIF) and to introduce a simple correction algorithm.

Method Computer simulations were performed to evaluate the influence of AIF peak saturation and to demonstrate the effectiveness of the presented correction algorithm. To compare the computer simulations with real MR data, MR perfusion measurements were performed on volunteers.

Results The computer simulations show that AIF peak saturation leads to a systematic overestimation of cerebral blood volume (CBV) and cerebral blood flow (CBF) values, which was confirmed by comparing the obtained MR data with PET results. With use of an improved calculation algorithm correcting for AIF peak saturation, a significant improvement of the obtained CBV and CBF values could be demonstrated.

Conclusion Our results suggest that AIF peak saturation leads to a significant systematic error in the determination of CBV and CBF values and has necessarily to be taken into account for dynamic contrast-enhanced MR perfusion studies.

From the Departments of Magnetic Resonance (R. Ellinger, C. Kremser, M. Schocke, S. Felber, and F. Aichner) and Anesthesia and Intensive Care Medicine (C. Kolbitsch), University of Innsbruck, Innsbruck, Austria; and Institute of Radiobiology, GSF–National Research Center of Environment and Health, Neuherberg, Germany (J. Griebel).

Address correspondence and reprint requests to Dr. C. Kremser at Department of Magnetic Resonance, University of Innsbruck, Anichstraβe 35, A-6020 Innsbruck, Austria. E-mail: christian.

© 2000 Lippincott Williams & Wilkins, Inc.