Acute and chronic paronychia revisited: A narrative review : Journal of Cutaneous and Aesthetic Surgery

Secondary Logo

Journal Logo

Review Article

Acute and chronic paronychia revisited

A narrative review

Relhan, Vineet; Bansal, Anuva

Author Information
Journal of Cutaneous and Aesthetic Surgery 15(1):p 1-16, Jan–Mar 2022. | DOI: 10.4103/JCAS.JCAS_30_21
  • Open


Paronychia refers to the inflammation of the tissue, which immediately surrounds the nail and it can be acute

(<6 weeks duration) or chronic (>6 weeks duration).[1] Disruption of the protective barrier between the nail plate and the adjacent nail fold preceded by infectious or noninfectious etiologies results in the development of paronychia. A combination of general protective measures, medical, and/or surgical interventions are required for management.[1,2] This review explores the pathogenesis, clinical features, differential diagnosis, and medical and surgical management of paronychia. For the purpose of this review, we searched the PubMed, Cochrane, and Scopus databases using the following keywords, titles, and medical subject headings (MeSH): acute paronychia (AP), chronic paronychia (CP), and paronychial surgeries. Relevant review articles, original articles, and case reports/series published till February 2020 were included in this article.


The nail bed comprises the proximal germinal matrix which gives rise to the new nail, whereas the distal sterile matrix adds volume and strength.[3,4] The paronychium constitutes the soft tissue lateral to the nail bed, whereas perionychium is the paronychium plus the nail bed.[2] The hyponychium is formed at the point where the distal nail bed meets the skin of the fingertip. The proximal nail fold (PNF) is an anatomic transition between the nail bed and the paronychium. Present at the most distal portion of the PNF, at the point of its attachment to the nail plate lies the cuticle or the eponychium, an outgrowth of the PNF and the nail vest, a thin veil of tissue forms at this junction.[2,4] This layout thus forms an efficient barrier to exogenous stimuli and its destruction heralds the onset of paronychia.[4]



This is an acute-onset (less than 6 weeks) inflammation of the tissue immediately surrounding the nail, most commonly occurring as a result of bacterial infection.


It is considered to be one of the most common hand infections and a female predominance has been reported with a female to male ratio of 3:1.[1]


Predisposing factors

The most common initiating factor for fingernail paronychia is nail trauma, often related to onychophagia, manicures, household wet-work, or retention of a foreign body associated with penetrating trauma.[2] AP of the toes occurs in most cases in association with ingrown toenails or onychocryptosis.


Infectious causes

AP is commonly caused by inoculation of the organisms present in the skin flora, such as Staphylococcus aureus and Streptococcus pyogenes into the nail folds, following the inciting trauma and subsequent disruption of the protective fingertip barrier.[5] Other aerobic bacteria such as gamma-hemolytic streptococci and Klebsiella pneumoniae constitute roughly 25% of the cases, whereas anaerobic organisms account for another 25%. Contact with oral secretions may predispose the digits to inoculation by either the skin flora or the oral flora, including aerobic bacteria such as Eikenella corrodens and anaerobic bacteria (e.g., Fusobacterium, Peptostreptococcus, Prevotella, and Porphyromonas spp.).[5] Contact with livestock may predispose to the acquisition of Pasteurella multocida.[2]Pseudomonas aeruginosa, Coliforms, and Proteus vulgaris have also been isolated.[2,6] Pseudomonas may be identified by a greenish discoloration of the nail bed.[7] Nonbacterial causative pathogens are uncommon causes and include Candida albicans and herpes simplex virus.[2]

Noninfectious causes

Pemphigus vulgaris, pustular psoriasis, and reactive arthritis may also present as AP.[2,8,9] Certain drugs have also been implicated in causing AP, within 1–3 months after treatment initiation, including epidermal growth factor receptor (EGFR) inhibitors, cytotoxic chemotherapeutic agents (taxanes, doxorubicin, methotrexate, capecitabine), systemic retinoids, and antiretroviral drugs.[10-13]

Clinical presentation

Patients present 2–5 days after the initiating cause, with acute onset erythema, edema, pain, and tenderness along the lateral and/or PNFs, generally involving a single digit[9,14] [Figure 1A]. Application of pressure along the nail fold may lead to the exudation of purulent material.[15,16] At times pustules, or a frank abscess [Figure 1B] may be seen and a “collar-stud” abscess may form if it connects with the underlying tissues and such deep-seated infection may damage the nail matrix.[14]

Figure 1:
(A) Acute paronychia presenting as erythema, swelling and pus discharge along the lateral and proximal nail fold. (B) Acute paronychia of the thumb with abscess formation

Paronychia associated with psoriasis, Reiter syndrome, and pemphigus may involve multiple digits and the presence of characteristic nail changes is also useful pointers.[2,9,17] Involvement of the periungual tissue in secondary syphilis or congenital syphilis may mimic acute bacterial paronychia, but is more gradual in onset and less painful.[18] Drug-induced AP may involve several digits and a temporal correlation helps in establishing the cause.[2] Furthermore, malignancies of the nail unit (such as glomus tumor), periungual region, metastasis, and paraneoplastic conditions may present as AP.[2] Recently, a case presenting with AP was diagnosed with subungual keratoacanthoma, a rare variant of keratoacanthoma.[19]

Differential diagnosis

Herpetic whitlow presents as painful grouped vesicopustules on an erythematous base which gradually coalesce into large-honeycomb-like bullae; however, frank pus-discharge is never seen. It should be considered in children who suck their thumbs leading to viral autoinoculation, healthcare providers, as well as following genital herpes exposure.[15,20] Incision and drainage are contraindicated and tzanck smear and/or culture are pivotal in diagnosis.[2,5,15]


A detailed history regarding the risk factors, onset, site, progression, and physical examination is necessary. Routine culture from expressed fluid or drained pus is not recommended, as the results are commonly nondiagnostic.[21-23] Ultrasonography (USG) reveals a diffuse thickening of the periungual fold, and can help delineate an abscess or cellulitis when it is not clinically evident.[24]

The digital pressure test is performed by asking the patient to oppose the thumb and index finger, thereby applying light pressure over the distal volar aspect of the affected digit. If an abscess is present, a well-demarcated area of blanching is seen.[25]


Management of AP may be nonsurgical or surgical depending upon the extent and/or severity of inflammation and presence of an abscess.[2,23]

Nonsurgical management

If diagnosed in the initial stages, AP without an abscess can be treated nonsurgically as described in Table 1. A substantial amount of inflammation, early abscess, or immunocompromised states warrant the initiation of systemic antibiotics[5,29,30] [Tables 2 and 3].

Table 1:
Medical management of acute paronychia
Table 2:
Recommendations for antibiotic use in acute paronychia
Table 3:
Choice of antibiotics for acute paronychia[5 , 29 , 30]


Subungual abscess, cellulitis, osteomyelitis, nail plate elevation, and dystrophy are uncommon complications of AP.[5,9,14,17] Rarely, an acquired periungual fibrokeratoma [Figure 2] may develop.[34] The course of AP may be further complicated by recurrences and chronicity. Furthermore, severe infection, diabetes, or other causes of immunosuppression may lead to impaired response to treatment.[2]

Figure 2:
Acquired periungual fibrokeratoma: complication of acute paronychia



CP is a recalcitrant dermatosis of more than 6 weeks duration, characterized by the inflammation (with or without infection) of the tissue surrounding the nail.[2,4,23]


CP is now deemed to be a form of hand eczema where exposure to environmental allergens plays a pivotal role, whereas colonization of the nail sulcus with candida, occurs only secondarily.[4,11,35,36] Recurring episodes of acute inflammation lead to fibrosis of PNF and LNF, causing them to retract, further exposing the nail sulcus.[2,4] As this vicious sequence continues, the capacity to restore the cuticle diminishes and a progressive impairment of the vascular supply of the inflamed and fibrosed PNF ensues[4,37] [Figure 3].

Figure 3:
Pathogenesis of CP-CP is form of hand dermatitis with secondary (bacterial/fungal) colonization. Repeated exposure to moisture and irritants leads to damage to the cuticle, causing unchecked entry of allergens as well as pathogens leading to repeated episodes of acute inflammation resulting in edema, fibrosis and consequent retraction of the nail folds. The nail sulcus is thus, further exposed compromising the effective seal again resulting in the unchecked entry of organisms/allergens. This vicious cycle impedes the cuticle regeneration. In addition, the fibrosis as well as progressive loss of vascular supply prevents topical and systemic drugs from reaching the nail folds. Thus, a failed treatment response perpetuates this cycle

Etiology and risk factors

Occupations associated with repeated exposure to moisture, irritants as well as allergens are seen in homemakers, bartenders, cooks, and health-care professionals, and constitute the most common etiological factor. Diabetes mellitus, HIV infection, and other causes of immunosuppression increase the risk of secondary colonization.[2,4,38] Uncommon causes include infections such as bacterial, fungal (e.g., Candida albicans), and viral,[2,38] Peri and/or subungual inflammation may be seen in secondary or congenital syphilis.[19] Paronychia associated with tuberculosis (TB) [Figure 4] includes painless paronychia (PP) as a result of primary inoculation TB in medical personnel or among patients infected with mycobacterium TB.[39,40] CP associated with TB verrucosa cutis, infection of the distal phalanx leading to contiguous involvement of the PNF and onychodystrophy with tubercular PP have also been reported.[41-43] Paronychia is also considered to be a rare variant of cutaneous leishmaniasis.[44,45] Metastatic cancer, subungual melanoma, squamous cell carcinoma (SCC) [Figure 5] should always be excluded when CP is atypical in presentation, involves a single digit or does not respond to conventional treatment.[4,5] Metastatic lesions to the nail bed tend to lift up the nail and the most common source is primary bronchogenic carcinoma.[46] Peripheral vascular disease (PVD) [Figure 6] and Raynaud’s phenomenon may also uncommonly present as CP.[47] Several drugs [Table 4] have been known to cause CP or a delayed complication such as periungual pyogenic granuloma.[4,48-51] Mechanisms include an increase in the retinoic acid concentrations and inhibition of EGFR.[2,52] Pemphigus [Figure 7], psoriasis [Figure 8] and reactive arthritis may also present with CP, although presentation as AP is more common.[2,8,9]

Figure 4:
Chronic paronychia associated with tuberculosis
Figure 5:
Chronic paronychia associated with an underlying malignancy (squamous cell carcinoma)
Figure 6:
Chronic paronychia associated with underlying peripheral vascular disease
Table 4:
Drugs causing paronychia
Figure 7:
Chronic paronychia with nail dystrophy in a patient with pemphigus vulgaris
Figure 8:
Chronic paronychia in a case of psoriasis vulgaris

Clinical features

CP presents with erythema, pain, and swelling involving the perionychium of >6 weeks duration and generally involves more than one fingernail.[2,4,23] [Figure 9] Pus discharge may be associated, but a frank abscess is not seen.[38] Associated nail matrix damage can lead to ridging, discoloration, Beau’s lines, and onychomadesis.[2,9,16,18] Green discoloration of the nail plate is a suggestive of Pseudomonas colonization.[7] Daniel et al.[53] proposed a severity scale for CP [Table 5]. Recently, a new severity index for the evaluation of CP has been proposed by Atiş et al.[54] [Table 6].

Figure 9:
Chronic paronychia showing erythema, pain and swelling involving the perionychium of multiple digits. Loss of cuticle is also visible
Table 5:
Severity scale for chronic paronychia proposed by Daniel et al.[53]
Table 6:
Objective severity index proposed by Atis et al.[52]

Diagnosis and differential diagnosis

A detailed history is essential including trauma, occupation, hobbies, drug intake, diabetes, HIV, or PVD. Examination findings include edema, erythema, tenderness, and retraction of the PNF along with absence of the adjacent cuticle, generally affecting multiple fingers. Associated nail changes may also be present. Recalcitrant or atypical case may require microscopy (gram staining, potassium hydroxide mount, tzanck smear) culture and/or biopsy, HIV testing, and blood sugar testing.

As compared to AP, CP has a gradual onset, is less painful, involves more than one digit, and can be associated with nail changes.[14] Cutaneous neoplasms as well as malignancies of the nail unit may present as paronychia and failure to respond to conventional therapy is an ominous sign.[2,55] In contrast, long-standing paronychia is considered to be a risk factor for the development of SCC.[56] Recurrent CP, involvement of single digit, and an absence of response to conventional therapy warrant a biopsy to rule out malignancy.


The treatment of CP consists of ending the source of irritation, impeding inflammation, allowing the cuticle to regenerate through general measures [Table 7], medical management, and/or surgical management.

Table 7:
Recommended general measures for prevention of chronic paronychia

Medical management

At present, topical corticosteroids (CS) are considered the mainstay of therapy and are considered to be superior to topical antibiotics and systemic antifungals with the use of the latter only recommended in case of accompanying candida infection[2,4,28,36] [Table 8].

Table 8:
Medical management of chronic paronychia


Surgical management in AP is reserved for patients with well-formed abscess/fluctuance or a run-around abscess; failure to respond to medical management and/or extensive involvement or fulminant infection of the eponychium.[2,66] The principle behind surgical intervention in the case of AP is to allow drainage of the purulent material and/or decompress an abscess if present.[67]

The indications for surgical management in CP include more than 6 months duration and lack of response to/failure of medical treatment.[4,67] The surgical approaches aid in removal of the chronically inflamed surrounding tissue fibrosis, aiding drug penetration and cuticular regrowth of the cuticle.[67]

Preoperative evaluation is discussed in Table 9.

Table 9:
Preoperative checklist

Intraoperative period

The digit to be operated upon is cleaned thoroughly with betadine and normal saline. A proximal digital block using 2 mL (1 mL on each side) of 2% lignocaine (without adrenaline) is preferred for anesthesia.[68]

The local infiltration of the anesthetic agent into the affected region is often ineffective and more painful than the administration of drugs of a digital block. The next step is application of a tourniquet to prevent excessive bleeding during the surgery. (If procedure lasts longer than 15 min, tourniquet should be released for a few minutes to allow reperfusion.)[69]

Surgical techniques for acute paronychia [ Table 10]

No-incision technique

  • A No. 11 or 15 scalpel blade (with cutting edge pointed away from nail plate); freer elevator, a hemostat or spatula is placed into the nail sulcus under the nail fold until the abscess is decompressed. The blade is inserted at the junction of the perionychium and the eponychium, extending proximally till the proximal nail edge is visualized. Next, the proximal one-third of the nail may be removed to ensure maximal pus drainage. The wound cavity is irrigated with isotonic sodium chloride. A small piece of mesh gauze may be placed beneath the nail fold allowing continued drainage and removed after 2 days[70,71] [Figure 10A].
  • The DAREJD technique uses a 21- or 23-gauge needle, to lift the lateral nail fold, at the point where it meets the nail itself, enabling egress of the purulent material. This is followed by wound dressing, and a 5-day course of antibiotics with no subsequent need for dressing[72] [Figure 10B].
Summary of Surgical techniques for acute paronychia
Figure 10:
(A) No-incision technique: scalpel blade with cutting edge away from nail plate is inserted at the junction of the lateral nail fold and proximal nail fold to allow spontaneous pus drainage. (B) DAREJD technique: needle inserted into the lateral nail fold and lifted to allow pus drainage

Single-incision technique

  • This procedure is recommended for large abscesses and those present at a distance from the nail sulcus as well as when the no-incision techniques are not successful[2,19,71] [Figure 11]. The wound is then irrigated with saline, packed with gauze, and dressing is done.
Figure 11:
Single-incision technique: for larger abscesses, number 11 or 15 blade is used to make an incision over the abscess allowing its drainage

Double-incision technique and Swiss roll technique

  • If the entire eponychium is involved, or a run-around abscess is present, longitudinal incisions can be made on both sides of the nail. Complete nail plate removal is reserved for subungual extension of abscess, causing nail plate separation from the underlying matrix[2,19,69] [Figure 12A].
  • Pabari et al.[4] described another technique known as the Swiss Roll technique for a run-around abscess [Figure 12B]. After the double incision, the nail fold is reflected proximally. The dressing is removed after 2 days, wound examined, and if found to be clean, the anchoring sutures are removed. The nail fold is placed back in its original position.[73]
Figure 12:
(A) Double-incision technique: when the abscess is large or entire eponychium is involved, incisions are made on both sides of the nail fold, the nail fold is reflected, cavity is irrigated and a gauze is placed inside. (B) Swiss Roll technique for a run-around abscess. After the double incision, the nail fold is reflected proximally over piece of gauze or nonadherent dressing and secured to the skin using two nonabsorbable stay sutures

Surgical techniques for chronic paronychia [ Table 11]

Eponychial marsupialization (with/without nail plate removal)

First introduced by Keyser and Eaton, this procedure involves the excision of a crescent-shaped portion of the PNF. The excision area includes all of the affected tissue, extends from one LNF to the other and starts 1 mm away from the distal margin of the eponychium stretching around 6 mm proximally [Figure 13]. The entire inflamed tissue within the margins of the crescent and going down to, but not including, the germinal matrix is excised and packed with gauze pieces. This helps to exteriorize the inflamed, obstructed nail matrix, enabling its drainage. Wound epithelization tends to occur in 2–3 weeks and conservation of the ventral aspect of the PNF, prevents the consequent roughness of the nail plate, thus, delivering a more cosmetically appealing result.[74] Concomitant nail removal in patients with nail plate irregularities was proposed by Bednar et al.[37] They suggested that nail removal more thoroughly debrides the entire nail fold by allowing drainage of both the volar portion of the dorsal roof as well as the ventral floor.

Table 11:
Summary of Surgical techniques for chronic paronychia
Figure 13:
Eponychial marsupialization: excision of a crescent-shaped portion of the dorsal aspect of the proximal nail fold. The excision area starts 1 mm away from the distal margin of the eponychium extending around 6 mm proximally

En bloc excision of the proximal nail fold

This technique, first described by Baran et al., involves the excision of a crescent-shaped segment, formed of the entire depth of the PNF, with a width of 5-6 mm, extending from one LNF to the other, without the concurrent removal of the nail plate [Figure 14A–C]. Complete regeneration of the PNF along with the cuticle is said to occur over a 12-week period. With a post-op normal attachment to the nail plate, minimal effect on the nail shininess the outcome is cosmetically and functionally acceptable. The distal most part of the eponychium is not conserved, as is done in the case of marsupialization, as the authors recommend that the inflamed, fibrosed nail fold with a reduced vascularity does not participate considerably in the nail and cuticular regrowth. It should be noted, however, that en bloc excision may lead to a postoperative lengthening of the nail plate.[75]A subsequent study, compared the results of en bloc excision of the PNF without nail plate removal to that with nail plate removal and concomitant nail avulsion was found to produce a better surgical outcome.[67]

Figure 14:
En bloc excision of the proximal nail fold: this technique involves the removal of a wedge-shaped crescent formed of the entire depth of the PNF, with a width of 5–6 mm, extending from one LNF to the other, without the removal of the nail plate

Swiss-roll technique

A modification of this technique may be used in CP, wherein the nail bed is kept exposed for 7 days to facilitate drainage of any purulent material. The advantages include preservation of the nail plate and lack of a skin defect which enables faster healing with good cosmetic and functional results.[4,73]

Square flap technique

A recently introduced procedure involves the excision of the fibrotic tissue without complete removal of PNF and LNF. Oblique incisions of length (4-5 mm) are made on both sides of the PNF. Next, an incision is made parallel to the epidermis, beneath the fibrosis, taking precautions so as to avoid injury to the nail matrix. The square flap thus created is lifted using forceps. The fibrotic tissue lying underneath is removed while conserving the epidermis of the PNF. A similar incision on the LNF can be used to remove lateral fibrosis, tilting the blade at a 45° angle. The square flap is repositioned and surgical closure is done using simple interrupted sutures [Figure 15A–F]. The epidermis of the proximal and LNF can be conserved using this technique [Figure 16]. However, it must be emphasized that the nail fold skin quality is of utmost value in the success of this technique.[68]

Figure 15:
(A–F) Square flap technique. (A) Oblique marking guidelines are made on both sides of the proximal nail fold. (B) Followed by incision along these markings. Next an incision is made parallel to the epidermis and beneath the fibrosis. (C) The square flap is lifted using a forceps. (D) The fibrotic tissue lying underneath is removed while saving the epidermis of the PNF. (E) A similar incision on the LNF can be used to remove latera fibrosis. (F) The square flap is kept in place and surgical closure is done using simple interrupted sutures
Figure 16:
Postop (square flap technique) photograph at 2 months. Healing was observed in 2 weeks and cuticular regrowth in 6 weeks

Postoperative period

Cleaning with an antibiotic solution once a day, application of a topical antibiotic and daily dressing are recommended. Oral antibiotics are administered for a period of 5–7 days and dressing may be continued for 1–2 weeks until healthy granulation tissue is seen.[67] Topical corticosteroid and/or antifungals may also be prescribed.[14] Counseling regarding strict avoidance of contact with irritant/allergens as is essential.[67] Complete healing is expected to occur in 2 weeks, whereas the cuticle regrowth takes around 6 weeks post-surgery.[68]

Postoperative complications

Secondary infection, pain, wound dehiscence, suture margin necrosis, hemorrhage, scarring, nail dystrophy, and relapse have been reported.[37,67] Other complications include long recovery intervals and a postoperative increase in the nail plate length due to PNF retraction.[68,77] Avoidance of irritant contact, hygiene, daily dressing, prevention of secondary infection can help prevent these.


Paronychia refers to the inflammation of the tissue which immediately surrounds the nail and can be acute or chronic. AP is most commonly bacterial in origin and presents as sudden onset redness, edema and pain with/without the formation of a frank abscess, along the LNF and/or PNF, commonly involving a single digit. If diagnosed early, AP, with mild inflammation and no abscess can be treated nonsurgically with warm soaks 3–4 times daily, topical antibiotic with/without a topical CS or a combination of these. Significant erythema or an abscess, necessitates use of systemic antibiotics. Surgical management in AP is reserved for a well-formed abscess, failure to respond to medical management, and/or extensive involvement. No randomized controlled trials have compared the various methods of drainage in AP and treatment should therefore be tailored to the clinical situation and skill of the physician.

CP presents with erythema, pain, and swelling involving the perionychium of >6 weeks duration, and generally involves multiple digits. Topical CS are considered the first-line treatment, whereas tacrolimus and topical antifungals are second line options. Surgical intervention is reserved for cases persisting for greater than 6 months, not responding to conservative measure. Various surgical approaches for CP such as marsupialization, en bloc excision of PNF, Swiss-roll technique and square flap technique aim at the removal of the fibrosed tissue facilitating drainage.



Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.


1. Rockwell PG. Acute and chronic paronychia. Am Fam Physician 2001 63 1113–6
2. Shafritz AB, Coppage JM. Acute and chronic paronychia of the hand. J Am Acad Orthop Surg 2014 22 165–74
3. Fleckman P. Structure and function of the nail unit. Scher RK, Daniel CR III Nails: diagnosis, therapy, surgery Oxford Elsevier Saunders; 2005 14
4. Relhan V, Goel K, Bansal S, Garg VK. Management of chronic paronychia. Indian J Dermatol 2014 59 15–20
5. Rigopoulos D, Larios G, Gregoriou S, Alevizos A. Acute and chronic paronychia. Am Fam Physician 2008 77 339–46
6. Brook I. Paronychia: a mixed infection. Microbiology and management. J Hand Surg Br 1993 18 358–9
7. Biesbroeck LK, Fleckman P. Nail disease for the primary care provider. Med Clin North Am 2015 99 1213–26
8. Lee HE, Wong WR, Lee MC, Hong HS. Acute paronychia heralding the exacerbation of pemphigus vulgaris. Int J Clin Pract 2004 58 1174–6
9. Baran R, Barth J, Dawber RP. Nail disorders: common presenting signs, differential diagnosis, and treatment New York, NY Churchill Livingstone; 1991 93–100
10. Robert C, Sibaud V, Mateus C, Verschoore M, Charles C, Lanoy E, et al Nail toxicities induced by systemic anticancer treatments. Lancet Oncol 2015 16 e181–9
11. Garden BC, Wu S, Lacouture ME. The risk of nail changes with epidermal growth factor receptor inhibitors: a systematic review of the literature and meta-analysis. J Am Acad Dermatol 2012 67 400–8
12. Figueiras Dde A, Ramos TB, Marinho AK, Bezerra MS, Cauas RC. Paronychia and granulation tissue formation during treatment with isotretinoin. An Bras Dermatol 2016 91 223–5
13. Sibel S, Macher A, Goosby E. Paronychia in patients receiving antiretroviral therapy for human immunodeficiency virus infection. J Am Podiatr Med Assoc 2000 90 98–100
14. Jebson PJ. Infections of the fingertip: paronychias and felons. Hand Clin 1998 14 547–55, viii
15. Habif TP. Nail diseases.Habif TP, editor. Clinical dermatology: a color guide to diagnosis and therapy4th ed Edinburgh Mosby; 2008. pp. 71–2
16. Tosti A, Piraccini BM. Nail disorders. Bolognia JL, Jorizzo JL, Rapini RP Dermatology1st ed London Mosby; 2003 1072–3
17. Baran R. Periungual nail disorders. Tosti A, Bristow I, Haneke E, Dawber RPR, Baran R A text atlas of nail disorders: techniques in investigation and diagnosis3rd ed UK CRC Press; 2003 82
18. Noriega L, Gioia Di Chiacchio N, Cury Rezende F, Di Chiacchio N. Periungual lesion due to secondary syphilis. Skin Appendage Disord 2017 2 116–9
19. Company-Quiroga J, Alique-García S, Martínez-Sánchez D. Atypical acute paronychia. Eur J Dermatol 2019 29 246–7
20. de Berker D, Baran R, Dawber RP. Disorders of the nails. Burns T, Breathnach S, Cox N, Griffiths S Rook’s textbook of dermatology7th ed Oxford Blackwell Science; 2005. pp. 62.1
21. Raff AB, Kroshinsky D. Cellulitis: a review. JAMA 2016 316 325–37
22. Choosing Wisely Campaign. Available from: [Last accessed on 2016 Aug 11]
23. Leggit JC. Acute and chronic paronychia. Am Fam Physician 2017 96 44–51
24. Aluja Jaramillo F, Quiasúa Mejía DC, Martínez Ordúz HM, González Ardila C. Nail unit ultrasound: a complete guide of the nail diseases. J Ultrasound 2017; 20 181–92
25. Turkmen A, Warner RM, Page RE. Digital pressure test for paronychia. Br J Plast Surg 2004 57 93–4
26. Marx J, Hockberger R, Walls R Handbook of Rosen’s emergency medicine: concepts and clinical practice8th ed. Philadelphia, PA Saunders; 2013 534–70
    27. Roberts JR, Hedges JR Incision and drainage: clinical procedures in emergency medicine6th ed. Philadelphia, PA Saunders; 2013 719–58
      28. Wollina U. Acute paronychia: comparative treatment with topical antibiotic alone or in combination with corticosteroid. J Eur Acad Dermatol Venereol 2001 15 82–4
      29. Chang P. Diagnosis using the proximal and lateral nail folds. Dermatol Clin 2015 33 207–41
      30. Fowler JR, Ilyas AM. Epidemiology of adult acute hand infections at an urban medical center. J Hand Surg Am 2013 38 1189–93
      31. Daum RS. Clinical practice. Skin and soft-tissue infections caused by methicillin-resistant staphylococcus aureus. N Engl J Med 2007 357 380–90
      32. Rerucha CM, Ewing JT, Oppenlander KE, Cowan WC. Acute hand infections. Am Fam Phys 2019 99 228–36
      33. Chiriac A, Brzezinski P, Foia L, Marincu I. Chloronychia: green nail syndrome caused by pseudomonas aeruginosa in elderly persons. Clin Interv Aging 2015 10 265–7
      34. Sezer E, Bridges AG, Koseoglu D, Yuksek J. Acquired periungual fibrokeratoma developing after acute staphylococcal paronychia. Eur J Dermatol 2009 19 636–7
      35. Hay RJ, Baran R, Moore MK, Wilkinson JD. Candida onychomycosis–an evaluation of the role of candida species in nail disease. Br J Dermatol 1988 118 47–58
      36. Tosti A, Piraccini BM, Ghetti E, Colombo MD. Topical steroids versus systemic antifungals in the treatment of chronic paronychia: an open, randomized double-blind and double dummy study. J Am Acad Dermatol 2002 47 73–6
      37. Bednar MS, Lane LB. Eponychial marsupialization and nail removal for surgical treatment of chronic paronychia. J Hand Surg Am 1991 16 314–7
      38. Dulski A, Edwards CW. Paronychia. StatPearls [Internet] Treasure Island, FL StatPearls Publishing; 2020. Available from: [Last accessed on 2020 May 14]
      39. Goette DK, Jacobson KW, Doty RD. Primary inoculation tuberculosis of the skin: Prosector’s paronychia. Arch Dermatol 1978 114 567–9
      40. O’Donnell TF Jr, Jurgenson PF, Weyerich NF. An occupational hazard–tuberculous paronychia. Report of a case. Arch Surg 1971 103 757–8
      41. Goh SH, Ravintharan T, Sim CS, Chng HC. Nodular skin tuberculosis with lymphatic spread: a case report. Singapore Med J 1995 36 99–101
      42. Khanna D, Chakravarty P, Agarwal A, Gupta R. Tuberculous dactylitis presenting as paronychia with pseudopterygium and nail dystrophy. Pediatr Dermatol 2013 30 e172–6
      43. da Silva Sousa AC, Sousa M, Tente D, Menezes N, Baptista A, Guedes R. Ungual tuberculosis: a unique clinical case. Skin Appendage Disord 2019 5 386–9
      44. Raja KM, Khan AA, Hameed A, Rahman SB. Unusual clinical variants of cutaneous leishmaniasis in Pakistan. Br J Dermatol 1998 139 111–3
      45. Iftikhar N, Bari I, Ejaz A. Rare variants of cutaneous leishmaniasis: whitlow, paronychia, and sporotrichoid. Int J Dermatol 2003 42 807–9
      46. Paringao AJ. A swollen draining thumb Am Fam Physician 2002 65 105–6
      47. Viswanath O, Peck J, Gill JS. An atypical presentation of Raynaud’s disease. Med Princ Pract 2019 28 394–6
      48. Wollina U. Systemic drug-induced chronic paronychia and periungual pyogenic granuloma. Indian Dermatol Online J 2018 9 293–8
      49. Habif TP. Nail disorders. Clinical dermatology: a color guide to diagnosis and therapy6th ed. Philadelphia, PA Elsevier; 2016. pp. 960–85
      50. Lacouture ME, Anadkat MJ, Bensadoun RJ, Bryce J, Chan A, Epstein JB, et al; MASCC Skin Toxicity Study Group Clinical practice guidelines for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicities. Support Care Cancer 2011 19 1079–95
      51. Capriotti K, Capriotti JA, Lessin S, Wu S, Goldfarb S, Belum VR, et al The risk of nail changes with taxane chemotherapy: a systematic review of the literature and meta-analysis. Br J Dermatol 2015 173 842–5
      52. Rigopoulos D, Gregoriou S, Belyayeva Y, Larios G, Gkouvi A, Katsambas A. Acute paronychia caused by lapatinib therapy. Clin Exp Dermatol 2009 34 94–5
      53. Daniel CR 3rd, Iorizzo M, Piraccini BM, Tosti A. Grading simple chronic paronychia and onycholysis. Int J Dermatol 2006 45 1447–8
      54. Atış G, Göktay F, Altan Ferhatoğlu Z, Kaynak E, Sevim Keçici A, Yaşar ş, et al A proposal for a new severity index for the evaluation of chronic paronychia. Skin Appendage Disord 2018 5 32–7
      55. Kuschner SH, Lane CS. Squamous cell carcinoma of the perionychium. Bull Hosp Jt Dis 1997 56 111–2
      56. Tambe SA, Patil PD, Saple DG, Kulkarni UY. Squamous cell carcinoma of the nail bed: the great mimicker. J Cutan Aesthet Surg 2017 10 59–60
      57. Daniel CR 3rd, Daniel MP, Daniel J, Sullivan S, Bell FE. Managing simple chronic paronychia and onycholysis with ciclopirox 0.77% and an irritant-avoidance regimen. Cutis 2004 73 81–5
      58. Baran R. Common-sense advice for the treatment of selected nail disorders. J Eur Acad Dermatol Venereol 2001 15 97–102
      59. Rigopoulos D, Gregoriou S, Belyayeva E, Larios G, Kontochristopoulos G, Katsambas A. Efficacy and safety of tacrolimus ointment 0.1% vs. Betamethasone 17-valerate 0.1% in the treatment of chronic paronychia: an unblinded randomized study. Br J Dermatol 2009 160 858–60
      60. Piraccini BM, Alessandrini A, Dika E, Starace M, Patrizi A, Neri I. Topical propranolol 1% cream for pyogenic granulomas of the nail: open-label study in 10 patients. J Eur Acad Dermatol Venereol 2016 30 901–2
      61. Cubiró X, Planas-Ciudad S, Garcia-Muret MP, Puig L. Topical timolol for paronychia and pseudopyogenic granuloma in patients treated with epidermal growth factor receptor inhibitors and capecitabine. JAMA Dermatol 2018 154 99–100
      62. Sibaud V, Casassa E, D’Andrea M. Are topical beta-blockers really effective “in real life” for targeted therapy-induced paronychia. Support Care Cancer 2019 27 2341–3
      63. Sollena P, Mannino M, Tassone F, Calegari MA, D’Argento E, Peris K. Efficacy of topical beta-blockers in the management of EGFR-inhibitor induced paronychia and pyogenic granuloma-like lesions: case series and review of the literature. Drugs Context 2019 8 212613
      64. Yen CF, Hsu CK, Lu CW. Topical betaxolol for treating relapsing paronychia with pyogenic granuloma-like lesions induced by epidermal growth factor receptor inhibitors. J Am Acad Dermatol 2018 78 e143–4
      65. Hachisuka J, Doi K, Moroi Y, Furue M. Successful treatment of epidermal growth factor receptor inhibitor-induced periungual inflammation with adapalene. Case Rep Dermatol 2011 3 130–6
      66. Shaw J, Body R. Best evidence topic report. Incision and drainage preferable to oral antibiotics in acute paronychial nail infection? Emerg Med J 2005 22 813–4
      67. Grover C, Bansal S, Nanda S, Reddy BS, Kumar V. En bloc excision of proximal nail fold for treatment of chronic paronychia. Dermatol Surg 2006 32 393–8; discussion 398-9
      68. Ferreira Vieira d’Almeida L, Papaiordanou F, Araújo Machado E, Loda G, Baran R, Nakamura R. Chronic paronychia treatment: square flap technique. J Am Acad Dermatol 2016 75 398–403
      69. Krunic AL, Wang LC, Soltani K, Weitzul S, Taylor RS. Digital anesthesia with epinephrine: an old myth revisited. J Am Acad Dermatol 2004 51 755–9
      70. Canales FL, Newmeyer WL 3rd, Kilgore ES Jr The treatment of felons and paronychias. Hand Clin 1989 5 515–23
      71. Paronychia Treatment & Management: Approach Considerations, Pharmacologic and Other Non-invasive Treatment, Drainage 2019. Available from: [Last accessed on 2020 May 31]
      72. Ogunlusi JD, Oginni LM, Ogunlusi OO. DAREJD simple technique of draining acute paronychia. Tech Hand Up Extrem Surg 2005 9 120–1
      73. Pabari A, Iyer S, Khoo CT. Swiss roll technique for treatment of paronychia. Tech Hand Up Extrem Surg 2011 15 75–7
      74. Keyser JJ, Eaton RG. Surgical cure of chronic paronychia by eponychial marsupialization. Plast Reconstr Surg 1976 58 66–70
      75. Baran R, Bureau H. Surgical treatment of recalcitrant chronic paronychias of the fingers. J Dermatol Surg Oncol 1981 7 106–7

      Acute; approach; chronic; paronychia; surgeries

      © 2022 Journal of Cutaneous and Aesthetic Surgery | Published by Wolters Kluwer – Medknow