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Intravascular ultrasound assisted carotid artery stenting: randomized controlled trial. Preliminary results on 60 patients

Chiocchi Marcello; Morosetti, Daniele; Chiaravalloti, Antonio; Loreni, Giorgio; Gandini, Roberto; Simonetti, Giovanni
Journal of Cardiovascular Medicine: Post Author Corrections: January 03, 2013
doi: 10.2459/JCM.0b013e32835898f1
Invited article: PDF Only


The primary aim is the evaluation of the usefulness of intravascular ultrasound (IVUS) in the identification of otherwise unnoticed complications during carotid stenting. The secondary aim is the evaluation of the impact of IVUS assistance in the procedural outcomes and long-term patency rates of carotid artery stenting.

Materials and methods

Sixty patients who underwent carotid artery stenting (CAS) during a 14-month period were evaluated prospectively. Thirty patients (50%) underwent IVUS assisted CAS, 30 patients (50%) underwent CAS using angiography as the unique diagnostic tool. All patients were enrolled through a primary duplex ultrasound evaluation; as a secondary evaluation, 54 patients (90%) underwent a preprocedural magnetic resonance angiography, whereas six patients (10%) underwent computed tomography-angiography. Patients with preocclusive stenoses (≥85%) were excluded. Mean follow-up was 23 ± 5.3 months.


No periprocedural or late complications were observed. No statistical significance was observed in long-term stent patency between the two groups. Mean procedural time length of IVUS-assisted procedures was 10.3 ± 5 min longer than non-IVUS-assisted procedures. Virtual histology (VH) IVUS evaluation of plaque morphology led to a different stent choice in three patients. In two cases, the IVUS assessment revealed a suboptimal stent deployment, solved by angioplasty; in one patient VH-IVUS detected plaque protrusion through stent cells, immediately treated by manual aspiration.


Though not recommended as a routine intraprocedural evaluation, IVUS may be useful for a real-time CAS control when treating challenging plaques, such as ‘soft’ or lipidic ones or those prone to rupture, or whenever an intraprocedural morphologic evaluation is required for the appropriate stent choice, or when higher embolic risk is evaluated.

Correspondence to Dr Antonio Chiaravalloti, MD, Università degli studi di Roma ‘Tor Vergata’ - Policlinico Tor Vergata, Viale Oxford, 81 - 00133 Roma, Lazio, Italy Tel: +06 20902400/0; e-mail:

Received 23 April, 2012

Revised 23 July, 2012

Accepted 26 July, 2012

© 2018 Italian Federation of Cardiology. All rights reserved.