Elevated peripheral (brachial) blood pressure (PBP) is related to hard cardiovascular outcomes and remains the main target for antihypertensive therapy. However, central aortic blood pressure (CABP) can be measured noninvasively and could potentially prove to be a more important marker of cardiovascular diseases in future. Several studies have shown association of CABP with cardiovascular mortality, coronary artery disease, left-ventricular hypertrophy and atherosclerosis. Furthermore, the impact of various classes of antihypertensive agents on CABP is different from their impact on PBP. We review the significance of CABP in cardiovascular outcomes and the differential impact of antihypertensive therapy on CABP.
aDepartment of Internal Medicine
bCardiovascular Section, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
Correspondence to Faisal Latif, MD, FACC, FSCAI, Assistant Professor of Medicine, Cardiovascular Section, University of Oklahoma Health Sciences Center, 920 Stanton L. Young Blvd, WP#3010, Oklahoma City, OK 73104, USATel: +1 405 323 9115; fax: +1 405 271 2619; e-mail: email@example.com
Received 25 August, 2011
Revised 4 October, 2011
Accepted 29 October, 2011