Research articles: InterventionsThe diagnostic accuracy of procalcitonin in infectious patients after cardiac surgery: a systematic review and meta-analysisLi, Qianqina,∗; Zheng, Shaoyia,∗; Zhou, Peng Yua; Xiao, Zezhoua; Wang, Ruilinga; Li, JuanbAuthor Information aDepartment of the Cardiovascular Surgery bSchool of Nursing, Southern Medical University, Guangzhou, China Correspondence to Juan Li, School of Nursing, Southern Medical University, Guangzhou 510515, China E-mail: [email protected] Received 23 April, 2019 Revised 4 April, 2020 Accepted 11 April, 2020 Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.jcardiovascularmedicine.com). Journal of Cardiovascular Medicine: April 2021 - Volume 22 - Issue 4 - p 305-312 doi: 10.2459/JCM.0000000000001017 Buy SDC Metrics Abstract Cardiac surgery with cardiopulmonary bypass (CPB) induces an acute inflammatory response that may lead to a systemic inflammatory response syndrome. The interest in procalcitonin (PCT) in the diagnosis of bacterial infection in patients after cardiac surgery remains less defined. The aim of this meta-analysis is to prospectively examine the discriminatory power of PCT as markers of infection in hospitalized patients with after cardiac surgery. The bivariate generalized nonlinear mixed-effect model and the hierarchical summary receiver operating characteristic model were used to estimate the pooled sensitivity, specificity and summary receiver operating characteristic curve. The pooled sensitivity and specificity were 0.81 (95% CI 0.75–0.87) and 0.78 (95% CI 0.73–0.83), respectively. The pooled positive likelihood ratio, and negative likelihood ratio of PCT were 3.74 (95% CI 2.98–4.69) and 0.24 (95% CI 0.17–0.32), respectively. The pooled area under the summary receiver operating characteristic curve of PCT using the HSROC method was 0.87 (95% CI 0.84– 0.90). This study indicated that PCT is a promising marker for the diagnosis of sepsis for those patients who undergo cardiac surgery. © 2020 Italian Federation of Cardiology - I.F.C. All rights reserved.